anti-Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) Antibodies

The protein encoded by LRAT is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Additionally we are shipping LRAT Kits (8) and LRAT Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
LRAT 9227 O95237
LRAT 79235 Q9JI60
LRAT 64047 Q9JI61
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Top anti-LRAT Antibodies at antibodies-online.com

Showing 10 out of 79 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of LRAT expression in HEK293T (A), SP2/0 (B), H9C2 (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from COLO205 cells, using LRAT Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human prostate carcinoma tissue, using LRAT Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ELISA, ICC, IF, IHC, WB ABIN6266814 at 1/100 staining human pancreas tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. Western blot analysis on COLO205 cell lysate using LRAT Antibody 100 μL Log in to see 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, WB 100 μL Log in to see Available
$363.46
Details
Human Rabbit Un-conjugated ELISA, IF, IHC, IHC (p), WB 50 μL Log in to see 11 to 14 Days
$484.00
Details
Human Mouse Un-conjugated ELISA, ICC, IF, IHC, WB Immunocytochemistry/Immunofluorescence: LRAT Antibody (M34-P1F10) [NBP2-50444] Immunohistochemistry: LRAT Antibody (M34-P1F10) [NBP2-50444] 0.1 mL Log in to see 7 to 9 Days
$347.48
Details
Human Mouse Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$537.17
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunofluorescence analysis of HuvEc cells, using LRAT Antibody . The picture on the right is treated with the synthesized peptide. Human Tonsil: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 11 to 13 Days
$768.40
Details
Human Rabbit Un-conjugated ELISA, IF, IHC (p), WB 200 μL Log in to see 12 to 14 Days
$438.90
Details

Top referenced anti-LRAT Antibodies

  1. Human Monoclonal LRAT Primary Antibody for ELISA - ABIN522683 : Guignard, Jin, Pequignot, Li, Chassigneux, Chekroud, Guillou, Richard, Hamel, Brabet: FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase. in The Journal of biological chemistry 2010 (PubMed)

More Antibodies against LRAT Interaction Partners

Human Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. The c.541-15T>G mutation in LRAT results in aberrant splicing and is therefore predicted to be causal for the early onset retinitis pigmentosa in this family.

  2. The genetic analysis performed on our proband showed a novel homozygous mutation on codon 119 of lecithin-cholesterol acyltransferase gene that causes the substitution of glycine by aspartate

  3. instability of LRAT(E14L) did not abrogate the production of the visual chromophore in a cell-based assay. Instead, expression of LRAT(E14L) led to a rapid increase in cellular levels of retinoic acid upon retinoid supplementation.

  4. LRAT hypermethylation was associated with decreased mRNA levels in colorectal cancer clinical specimens.

  5. lecithin retinol acyltransferase affects all-trans retinoic acid levels and has a role in retinoid sensitivity in malignant melanoma cells.

  6. These findings reveal structural adaptation that facilitates selective catalysis and mechanism responsible for diverse substrate specificity within the LRAT-like enzyme family

  7. high LRAT expression in melanoma might be important in removing retinol as substrate for RA production, thereby inducing signalling pathways leading to dedifferentiation, proliferation and anti-apoptosis

  8. Functional hepatic stellate cells coexpressing both LRAT and CRBP-1, that continue to maintain the ability to store vitamin A, contribute in part to the development of portal and parenchymal fibrogenesis in patients with viral hepatitis.

  9. Lecithin-retinol acyltransferase is a thermostable and highly active enzyme with a likely mode of interfacial activation.

  10. A genetic defect was identified in LRAT as a novel cause of retinitis punctata albescens.

  11. Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT.

  12. LRAT mutations cause a severe, early childhood onset, progressive retinal dystrophy.

  13. This study showed that malignant melanoma cells are able to esterify all-trans retinol and subsequently isomerize all-trans retinyl esters (RE) into 11-cis retinol, whereas their benign counterparts-melanocytes are not able to catalyze these reactions.

  14. Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis.

  15. LRAT expression is higher in renal tumors with an indolent biological behavior

  16. Conserved residues Cys-161 and His-60 form the essential catalytic dyad of LRAT that represents a novel thiol protease motif, which functions in an acyltransferase reaction.

  17. LRAT has a role in preventing progression of invasive bladder cancer

  18. Results provide evidence that multiple LRAT mRNA transcripts, which are expressed in a tissue-specific manner, may result from differential splicing of the 5'UTR region and the use of multiple polyadenylation signals in the 3'UTR.

  19. LRAT has a role in retinoid absorption and storage

  20. These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase.

Cow (Bovine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. These experiments are consistent with an expanded role for LRAT function as a protein palmitoyl transferase.

  2. LRAT is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 with membranes is neither dependent upon LRAT nor the result of S-palmitoylation

Mouse (Murine) Lecithin Retinol Acyltransferase (Phosphatidylcholine--Retinol O-Acyltransferase) (LRAT) interaction partners

  1. Rod a-wave and cone b-wave amplitudes of electroretinograms were increased in Cntf (-/-) mice, but rod b-wave amplitudes were unchanged compared with those in WT mice. Up-regulated RPE65 and LRAT levels accelerated both the visual cycle rate and recovery rate of rod light sensitivity in Cntf (-/-) mice.

  2. examined LRAT regulatory region is sufficient to achieve strong and selective expression in the eye and testes but not in liver and other organs

  3. LRAT overexpression diminishes intracellular levels of biologically active retinoids and reduces retinoid antitumor efficacy in the murine melanoma

  4. Mislocalized M-opsin was degraded whereas mislocalized S-opsin accumulated in Lrat(-/-) cones before the onset of massive ventral/central cone degeneration.

  5. Studies provide mechanistic insights into how vitamin A is distributed to peripheral tissues in a regulated manner and identify LRAT as a critical component of this process.

  6. Lrat KO mice exhibited increased levels of retinoic acid-responsive genes, including p21.

  7. Analyses revealed that LRAT undergoes spontaneous, covalent modification upon incubation with a variety of phosphatidylcholine substrates. The addition of an acyl chain occurs at the Cys(161) residue, indicating formation of a thioester intermediate.

  8. FATP1 inhibits 11-cis retinol formation via interaction with the visual cycle retinoid isomerase RPE65 and lecithin:retinol acyltransferase

  9. Data show that overexpression of human LRAT specifically in mice oral basal epithelial cells makes these cells more sensitive to carcinogen induced tumorigenesis.

  10. Lecithin-retinol acyltransferase is essential for accumulation of all-trans-retinyl esters in the eye and in the liver

  11. LRAT has a role in retinoid absorption and storage

  12. LRAT-/- mice are much more susceptible to vitamin A deficiency and should be an excellent animal model of vitamin A deficiency

  13. analysis of the topology and subcellular localization of LRAT, a critical enzyme in vitamin A metabolism

  14. LRAT is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 with membranes is neither dependent upon LRAT nor the result of S-palmitoylation

  15. Three Lrat mouse lines with genetic modifications were generated. This feature allows the disruption of this gene in any tissue of choice, by intercrossing with mice in which Cre-recombinase expression is driven by an appropriate tissue-specific promoter.

  16. LRAT acts together with Cyp26A1, one of the enzymes that catalyze the degradation of retinoic acid, and possibly with STRA6, the recently identified cell surface receptor for retinol-RBP

  17. These data show that the Lrat-/- and Rpe65-/- mice are comparable models for studies of Leber congenital amaurosis and that the destructive cone opsin mistrafficking is caused by the lack of 11-cis retinal.

  18. proximal region together with basal transcription factors may be sufficient to drive Lrat expression.

LRAT Antigen Profile

Protein Summary

The protein encoded by this gene is a microsomal enzyme that catalyzes the esterification of all-trans-retinol into all-trans-retinyl ester, an essential reaction for the retinoid cycle in visual system and vitamin A status in liver. Mutations in this gene have been associated with early-onset severe retinal dystrophy.

Gene names and symbols associated with LRAT

  • lecithin retinol acyltransferase (LRAT) antibody
  • lecithin-retinol acyltransferase (phosphatidylcholine-retinol-O-acyltransferase) (Lrat) antibody
  • lecithin retinol acyltransferase (Lrat) antibody
  • 1300010A18Rik antibody
  • AI449251 antibody
  • LCA14 antibody

Protein level used designations for LRAT

lecithin retinol acyltransferase , phosphatidylcholine--retinol O-acyltransferase , phosphatidylcholine-retinol-O-acyltransferase , lecithin retinol acyltransferase (phosphatidylcholine--retinol O-acyltransferase)

GENE ID SPECIES
9227 Homo sapiens
281285 Bos taurus
79235 Mus musculus
64047 Rattus norvegicus
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