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LMAN2 encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane.
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data thus reveal a Golgi-traversing pathway for exosomal release of the cargo protein GPRC5B in which CD2AP (show Cd2ap ELISA Kits) facilitates the entry and LMAN2 impedes the exit of the flux, respectively.
Interaction with VIP36 is dependent on glycosylation at the same sites that allow GC-C (show GUCY2C ELISA Kits) to fold and bind ligand.
Results identify the glycoprotein alpha1-antitrypsin as a cargo of VIP36.
VIP36 interacts with molecular chaperone (show HSP90AA1 ELISA Kits) BiP (show GDF10 ELISA Kits) and has a role in the quality control of secretory proteins
selective interaction of VIPL and VIP36 with the deglucosylated trimannose in the D1 branch of high-mannose-type oligosaccharides but with different pH dependence.
This gene encodes a type I transmembrane lectin that shuttles between the endoplasmic reticulum, the Golgi apparatus and the plasma membrane. The encoded protein binds high mannose type glycoproteins and may facilitate their sorting, trafficking and quality control.
lectin, mannose-binding 2
, glycoprotein GP36b
, vesicular integral protein of 36 kDa
, vesicular integral-membrane protein 36
, vesicular integral-membrane protein VIP36
, lectin mannose-binding 2
, Vesicular integral-membrane protein 36