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Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.. Additionally we are shipping Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Antibodies (109) and Low Density Lipoprotein Receptor-Related Protein Associated Protein 1 Kits (8) and many more products for this protein.
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data also reveal that D1D2 is able to bind to a second distinct site on LRP1 (show LRP1 Proteins) to form a monovalent complex. The studies confirm the canonical model for ligand recognition by this class of receptors, which is initiated by pairs of lysine residues that dock into acidic pockets on the receptor
The clinical and biometric features we describe in this report characterize LRPAP1-related high myopia and should raise suspicion for mutations in the gene.
The inhibition caused by reagents that prevented the activation of Rap was reversed by mobilizing intracellular calcium pharmacologically, whereas that caused by acrosome reaction inhibitors that impeded Rab3 (show RAB3A Proteins)'s binding to GTP (show AK3 Proteins) was not.
The LRPAP1 I allelic variant may be considered a candidate gene for PD, predominantly in patients having the APOE (show APOE Proteins) epsilon4 allelic variant.
RAP inhibited light chain (LC)endocytosis by approximately 88% and ameliorated LC-induced cytokine responses and epithelial-to-mesenchymal transformation in human proximal tubular cells.
Mutations in LRPAP1 are associated with severe myopia in humans.
Data indicate that the region of complement-type repeats 2-5 in LDLR (show LDLR Proteins) was identified as the binding site for FVIII (show F8 Proteins) and for alpha-2-macroglobulin receptor-associated protein (RAP).
LRP1 (show LRP1 Proteins)-C/T, A2M (show A2M Proteins)-Ile/Val and APOE (show APOE Proteins)-epsilon 2/epsilon 3/epsilon 4 polymorphisms are associated with AD.
Findings reveal that RAP is a novel Abeta (show APP Proteins)-binding protein that promotes cellular internalization of Abeta (show APP Proteins).
Adenoviral-mediated expression of human receptor-asociated protein RAP in a murine model of von Willebrand disease results in a continuous rise in FVIII (show F8 Proteins) over 6 days.
RAP deficiency attenuated atherosclerosis without influencing abdominal aortic aneurysms in hypercholesterolemic mice infused with angiotensin II.
In RAP-deficient mice megalin expression was strongly reduced and restricted to a subapical localization and NaP(i)-IIa protein distribution and abundance in the kidney was not altered.
the His-sRAP (show SRA1 Proteins)-induced acceleration of megalin (show LRP2 Proteins)-mediated endocytosis causes phosphaturia via altered subcellular distribution of NaPi-II [39-kD receptor-associated protein (RAP)]
Results suggest that receptor-associated protein (show BCAP31 Proteins) is required for the establishment of thyroglobulin (show TG Proteins) reservoirs, but its absence does not affect hormone secretion.
RAP binds to LPL (show LPL Proteins) with high affinity both in purified systems and cell extracts and RAP-deficient adipocytes secrete poorly assembled LPL (show LPL Proteins)
RAP is expressed by thyrocytes in a TSH-dependent manner, both in cultured thyroid cells and in vivo
Disruption of the RAP gene determines not only thyroid abnormalities, but also a severe defect of megalin (show LRP2 Proteins) expression and function in the kidney.
Receptor-associated protein (RAP) plays a central role in modulating Abeta (show APP Proteins) deposition in APP (show APP Proteins)/PS1 (show PSEN1 Proteins) transgenic mice
Interacts with LRP1/alpha-2-macroglobulin receptor and glycoprotein 330.
alpha-2-macroglobulin receptor-associated protein
, low density lipoprotein receptor-related protein associated protein 1
, alpha-2-macroglobulin receptor-associated protein 1
, lipoprotein receptor associated protein
, low density lipoprotein receptor-related protein-associated protein 1
, low density lipoprotein-related protein-associated protein 1 (alpha-2-macroglobulin receptor-associated protein 1)
, receptor-associated protein
, gp330-binding 45 kDa protein
, Alpha-2-macroglobulin receptor-associated protein precursor (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP) (Heparin binding protein-44) (HBP-44)
, heparin-binding protein 44
, low density lipoprotein receptor related protein, associated protein 1