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Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity). Additionally we are shipping MDGA1 Kits (5) and and many more products for this protein.
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MDGAs regulate the formation of neuroligin-neurexin (show NRXN1 Antibodies) trans-synaptic bridges by sterically blocking access of neurexins to neuroligins.
The MDGA1 gene may confer risk to schizophrenia and bipolar disorder in Chinese Han population.
A novel human gene mapped to chromosome 6p21, encodes a putative glycosylphosphatidylinositol (GPI (show GNPDA1 Antibodies)) anchored protein containing a MAM (show ATF7IP Antibodies) (meprin, A5 antigen (show NRP1 Antibodies), protein tyrosine phosphatase mu (show PTPRM Antibodies)) domain. (GPIM)
MDGA1, a novel glycosylphosphatidylinositol-anchored protein, is localized in lipid rafts.
MDGA1 is a new schizophrenia susceptibility gene, and altered neuronal migration is involved in SZ pathology.
Mdga1 is involved in the migration and positioning of a subset of cortical neurons and the radial migration of upper-layer neurons might be differentially regulated.
We conclude that MDGA1 acts cell autonomously to control the migration of MDGA1-expressing superficial layer cortical neurons.
These findings show that MDGA1 is a unique marker for studies of cortical lamination and area patterning and together with recent reports suggest that MDGA1 has critical functions in forebrain/midbrain development.
Required for radial migration of cortical neurons in the superficial layer of the neocortex (By similarity).
GPI and MAM protein
, MAM domain-containing glycosylphosphatidylinositol anchor protein 1
, MAM domain-containing protein 3