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MS4A6E encodes a member of the membrane-spanning 4A gene family.
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Common variants at MS4A4 (show MS4A4A Antibodies)/MS4A6E, CD2AP (show Cd2ap Antibodies), CD33 (show CD33 Antibodies) and EPHA1 (show EPHA1 Antibodies) are associated with late-onset Alzheimer's disease.
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.3, among a cluster of family members.
membrane-spanning 4-domains subfamily A member 6E