N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) Proteins (NAT1)

NAT1 is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. Additionally we are shipping NAT1 Antibodies (79) and NAT1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
NAT1 9 P18440
NAT1 17960 P50294
NAT1 116631 P50297
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top NAT1 Proteins at antibodies-online.com

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$4,331.68
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$405.71
Details
Escherichia coli (E. coli) Human His tag 50 μg Log in to see 15 to 19 Days
$407.00
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
Details
Yeast Cat His tag   1 mg Log in to see 60 to 71 Days
$2,665.67
Details
Yeast Rat His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details
Yeast Rabbit His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details
Yeast Cow His tag   1 mg Log in to see 60 to 71 Days
$2,764.67
Details

NAT1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced NAT1 Proteins

  1. Human NAT1 Protein expressed in Wheat germ - ABIN1311997 : Millner, Doll, Cai, States, Hein: Phenotype of the most common "slow acetylator" arylamine N-acetyltransferase 1 genetic variant (NAT1*14B) is substrate-dependent. in Drug metabolism and disposition: the biological fate of chemicals 2011 (PubMed)
    Show all 2 Pubmed References

More Proteins for N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) Interaction Partners

Human N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) interaction partners

  1. identified a novel endogenous role for human NAT1 (show EIF4G2 Proteins) that might explain some of its effects in cancer cell growth and survival

  2. N-acetyltransferase polymorphisms are associated with risk of lymphoma subtypes.

  3. The association of colorectal adenomas with the rs6983267 variant at 8q24 was considered as 'highly credible', the 'less credible' associations were identified with a further four variants of four independent genes: MTHFR (show MTHFR Proteins) c.677C>T p.A222V(rs1801133), TP53 (show TP53 Proteins) c.215C>G p.R72P (rs1042522), NQO1 (show NQO1 Proteins) c.559C>T p.P187S (rs1800566), and NAT1 (show EIF4G2 Proteins) alleles imputed as fast acetylator genotypes. [meta-analysis]

  4. NAT1 (show EIF4G2 Proteins) genotype affects thioguanine nucleotide levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs.

  5. NAT1 (show EIF4G2 Proteins) genetic polymorphisms were found to be a risk factor for smokers in the Black population of South Africa with esophageal squamous cell carcinoma.

  6. NAT1 (show EIF4G2 Proteins) has a role in the metabolic pathway of nicotine/cotinine and/or their metabolites.

  7. We report that miR (show MLXIP Proteins)-1290 directly targets the NAT1 (show EIF4G2 Proteins) 3'-UTR and that NAT1 (show EIF4G2 Proteins) protein expression is correlated with improved OS of breast cancer patients.

  8. Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine

  9. Candidate gene NAT1 (show EIF4G2 Proteins) were elevated in male breast cancer biopsies compared to those from female patients without regard to Estrogen Receptors status.

  10. Data suggest that NAT1 (show EIF4G2 Proteins)/NAT2 participate in biotransformation of many aromatic/heterocyclic amines; molecular models have been developed regarding acetylation mechanism, active site structure, and substrate/inhibitor-binding specificity. [REVIEW]

Mouse (Murine) N-Acetyltransferase 1 (Arylamine N-Acetyltransferase) (NAT1) interaction partners

  1. our results suggest that Nat1 (show EIF4G2 Proteins) deficiency results in mitochondrial dysfunction, which may constitute a mechanistic link between this gene and insulin (show INS Proteins) resistance .

  2. Differences between murine arylamine N-acetyltransferase type 1 and human arylamine N-acetyltransferase type 2 (show NAT2 Proteins) defined by substrate specificity and inhibitor binding.(

  3. In adipocytes, Nat1 (show EIF4G2 Proteins) silencing lowered insulin (show INS Proteins)-mediated glucose uptake, raised lipolysis, and decreased differentiation. Overexpression did the opposite. Nat1 (show EIF4G2 Proteins)(-) mice had high fasting blood glucose, insulin (show INS Proteins), and triglycerides and low insulin (show INS Proteins) sensitivity.

  4. Transfection assays in mice using hydrodynamics-based procedure and reporter gene assay in a mouse cell line revealed that glucocorticoid-induced NAT (show BRD2 Proteins) gene expression is species dependent

  5. NAT1 (show EIF4G2 Proteins) affects cell growth and morphology

  6. Biochemical analysis demonstrated that mNAT1 and its evolutionarily conserved co-subunit, mARD1, assemble to form a functional acetyltransferase.

  7. Results suggest that peroxynitrite-dependent inactivation of NAT1 (show EIF4G2 Proteins) and 2 may contribute to muscle dysfunction by impairing the biotransformation activity of this key cellular defense enzyme system.

NAT1 Protein Profile

Protein Summary

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with NAT1

  • N-acetyltransferase 1 (NAT1)
  • N-acetyl transferase 1 (Nat1)
  • N-acetyltransferase 1 (Nat1)
  • N-acetyltransferase 1 (arylamine N-acetyltransferase) (NAT1)
  • eukaryotic translation initiation factor 4, gamma 2, pseudogene 1 (Eif4g2-ps1)
  • arylamine N-acetyltransferase 1-like (LOC101095575)
  • N-acetyltransferase 1 (arylamine N-acetyltransferase) (Nat1)
  • AAC1 protein
  • AT-I protein
  • DRCF-6 protein
  • Eif4g2 protein
  • MNAT protein
  • Nat protein
  • Nat-1 protein
  • NAT1 protein
  • NATI protein

Protein level used designations for NAT1

N-acetyltransferase type 1 , arylamide acetylase 1 , arylamine N-acetyltransferase 1 , monomorphic arylamine N-acetyltransferase , N(alpha)-acetyltransferase 15, NatA auxiliary subunit , N-acetyl transferase 1, liver, blood , AT-1 , N-acetyltransferase (arylamine N-acetyltransferase) , N-acetyltransferase 1 (arylamine N-acetyltransferase) , NAT-1 , MNAT , Arylamide acetylase 1 , Monomorphic arylamine N-acetyltransferase , NAT1 9 , acetyltransferase AT-I , arylamine acetyltransferase

GENE ID SPECIES
9 Homo sapiens
17960 Mus musculus
116631 Rattus norvegicus
512603 Bos taurus
100328959 Oryctolagus cuniculus
171362 Rattus norvegicus
101095575 Felis catus
101840278 Mesocricetus auratus
Selected quality suppliers for NAT1 Proteins (NAT1)
Did you look for something else?