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NAT2 encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Additionally we are shipping NAT2 Antibodies (63) and NAT2 Proteins (9) and many more products for this protein.
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Our findings suggested that NAT2 (show SLC38A1 ELISA Kits) gene polymorphism rs1799931 was associated with decreased risk of acute myeloid leukemia (show BCL11A ELISA Kits) and was likely to be a protective factor against acute myeloid leukemia (show BCL11A ELISA Kits) development.
Study reestablished the association between NAT2 (show SLC38A1 ELISA Kits) SA and isoniazid-induced liver injury in a Singaporean population and demonstrated its clinical validity in prediction of isoniazid-induced liver injury.
In non-syndromic cleft lip with or without cleft palate, we found a significant association between the EGF61 (rs4444903) and NSCL (show NHLH1 ELISA Kits)/P (P = .01) genes. Conversely, NAT2 (show SLC38A1 ELISA Kits) (rs1799929) was not significantly different between the cases and the control group
182 Hungarian bladder cancer cases and 78 cancer-free controls were investigated. It was not possible to establish a particular impact of NAT2 (show SLC38A1 ELISA Kits)*6A and *7B genotypes (15 cases, 8%, 5 controls, 7%). GSTT1 (show GSTT1 ELISA Kits) exerted no marked influence on bladder cancer (negative 21% cases vs. 22% controls). The portion of GSTM1 (show GSTM1 ELISA Kits) negative bladder cancer patients was increased (63% cases vs. 54% controls).
Various antitubercular isoniazid dosing regimens have been proposed for NAT2 (show SLC38A1 ELISA Kits)-specific immunocompetent and immune-deficient patient populations.
Data suggest that metabolism (and possibly pharmacokinetics) of hypnotic nitrazepam involves liver enzymes AOX1 (aldehyde oxidase 1 (show AOX1 ELISA Kits)), NAT2 (N-acetyltransferase 2), AADAC (arylacetamide deacetylase (show AADAC ELISA Kits)), and CYP3A4 (cytochrome P450 3A4 (show CYP3A4 ELISA Kits)).
The multicolor melting curve assay described in our study is very promising for the efficient determination of NAT2 (show SLC38A1 ELISA Kits) genotype, and can facilitate the personalized dosing of isoniazid
No significant differences in the acetylator NAT2 (show SLC38A1 ELISA Kits) haplotype and phenotype distributions were found between Native American populations practicing farming and/or herding and those practicing hunting and gathering.
In any patient who may receive INH and happens to be NAT2 (show SLC38A1 ELISA Kits) slow acetylator type, NAT2 (show SLC38A1 ELISA Kits) genotype by covert action may influence the clinical response of above drugs.
Homozygous mutant allele of NAT2 (show SLC38A1 ELISA Kits) gene at 481site may act as a predisposing factor for phenytoin intoxication among tuberculous meningitis or tuberculoma patients having seizures.
Overexpression of X-box binding protein-1 (show XBP1 ELISA Kits) led to a marked increase in luciferase activity in P19 (show CDKN2D ELISA Kits) cells transfected with the Slc38a1 (show SLC38A1 ELISA Kits) reporter plasmid. These results suggest that theanine accelerates cellular proliferation and subsequent neuronal specification through a mechanism relevant to upregulation of Slc38a1 (show SLC38A1 ELISA Kits) gene in undifferentiated neural progenitor cells
We found that MeCP2 acts as a microglia-specific transcriptional repressor of
It was concluded that an acute colonic inflammation impairs the expression and function of NAT2 enzyme, thereby diminishing the capacity for 5-aminosalisylic acid metabolism by colonic mucosa.
GlnT would promote both proliferation and neuronal differentiation through a mechanism relevant to the upregulation of particular proneural genes in undifferentiated P19 cells.
Inner hair cells express glutamine transporter SLC38A1 (show SLC38A1 ELISA Kits).
Hyperhomocysteinemia-induced decrease of peroxynitrite level is associated with an increase of hepatic Nat2 isoform activity with a reversal effect of wine polyphenol extract supplementation.
In this study, the in vivo endothelial membrane localization of the sodium-dependent glutamine (show GFPT1 ELISA Kits) transporters Snat3 (Slc38a3 (show SLC38A3 ELISA Kits)) and Snat1 (Slc38a1 (show SLC38A1 ELISA Kits)) was investigated in the mouse brain microvasculature.
Mouse NAT2 is likely to influence epigenetic gene control, particularly of its own locus, and this is consistent with recent evidence associating aberrant mouse Nat2/human NAT1 (show EIF4G2 ELISA Kits) gene expression with certain developmental malformations and cancers.
Nat2 knockout mouse line demonstrates that different Nat2 isoforms have distinct functions with no compensatory expression, in Nat2 knockout animals, of the other isoforms.
Variation in capacity for acetylation of 4ABP and PABA resulting from endogenous murine NAT2 alleles is insufficient to affect 4ABP genotoxicity in liver.
The study is the first to thoroughly characterize the properties of a polymorphic NAT isoenzyme in a non-human primate model.
This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).
, N-Acetyltransferase-2 (arylamine N-acetyltransferase)
, N-acetyltransferase 2 (arylamine N-acetyltransferase)
, N-acetyltransferase type 2
, arylamide acetylase 2
, arylamine N-acetyltransferase 2
, N-acetyl transferase 2
, lambda R-1
, polymorphic arylamine N-acetyltransferase
, Arylamide acetylase 2
, NAT2 15
, Polymorphic arylamine N-acetyltransferase
, arylamine N-acetyltransferase-2
, N-system amino acid transporter 2
, amino acid transporter A1
, sodium-coupled neutral amino acid transporter 1
, system A amino acid transporter 1
, system N amino acid transporter 1