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Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. Additionally we are shipping Organic Cation Transporter 3 Antibodies (43) and Organic Cation Transporter 3 Kits (3) and many more products for this protein.
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The genotype of rs3088442 within the SLC22A3-LPAL2-LPA gene cluster may contribute to regulation of plasma Lp(a) levels and possibly to the severity of coronary artery disease in a Chinese Han population.
Findings suggest specific involvement of each organic cation transporters (OCT1 (show POU2F1 Proteins)-3) in drug transportation.
Findings suggest that OCT3 (show POU5F1 Proteins) plays an important role in the absorption and elimination of metformin and that the transporter is a critical determinant of metformin bioavailability, clearance, and pharmacologic action.
The markers of EMT (show ITK Proteins) were detected by using Western blot.
Findings suggest a negative feedback mechanism against inflammatory response by which solute carrier family 22 member 3 (SLC22A3) variant rs3088442 G-->A decreased the risk of coronary heart disease (CHD (show CHDH Proteins)).
Cultured astroctye line 1321N1 and primary human astrocytes transport monoamines partly through OCT3 (show POU5F1 Proteins).
There was no association between rs7758229 in 6q26-q27/SLC22A3 and the risk of colorectal cancer in a Chinese population.
Decreasing expression of OCT3 and MATE1 in human placenta indicates these transporters may play a role in fetal protection preferentially at earlier stages of gestation.
Our studies demonstrate that genetic polymorphisms in the proximal promoter region of OCT3 (show POU5F1 Proteins) alter the transcription rate of the gene and may be associated with altered expression levels of OCT3 (show POU5F1 Proteins) in human liver.
The increased Wnt3 (show WNT3 Proteins) in the trastuzumab-resistant cells also promoted a partial EMT (show ITK Proteins)-like transition.
Metformin undergoes negligible metabolism, these results imply that intestinal absorption of metformin is mediated at least in part by Oct3 (show POU5F1 Proteins) in mice.
Study showed that few, if any, 5-HT (show DDC Proteins) neurons in the dorsal raphe are resistant to loss of Pet-1 (show FEV Proteins) for expression of Slc22a3
These results demonstrate that OCT3 (show POU5F1 Proteins) is responsible for metformin accumulation and secretion in salivary glands.
Data indicate that the expression of the organic cation transporters Slc22a1 (show SLC22A1 Proteins), Slc22a2 (show SLC22A2 Proteins) and Slc22a3 essential for the cellular uptake of metformin was highly suppressed in Tsc1 (show TSC1 Proteins)+/-renal tumours.
Transcripts encoding OCT1-3 and ChAT (choline acetyltransferase) have been detected in tracheal epithelial cells; these data suggest that cells lining the airway are able to synthesize/secrete acetylcholine into the lumen.
evidence for a new means of downregulating IL-4 (show IL4 Proteins) production by basophils, both in vitro and in vivo, through OCT3 (show POU5F1 Proteins) targeted by 5-HT (show DDC Proteins) and pharmacologic ligands.
these results show that reduced 5-HT (show DDC Proteins) clearance following HPA (show HPSE Proteins) axis activation is likely mediated, at least in part, by the corticosterone-sensitive OCT3 (show POU5F1 Proteins)
Slc22a3 is one of three imprinted genes on chromosome 17 that is expressed from the maternal allele. A non-coding Air RNA is required for repression of all three genes on the paternal allele.
In 5HT transporter (show SLC6A4 Proteins)-deficient mice, OCT3 (show POU5F1 Proteins) mRNA concentrations were significantly increased in the hippocampus, but not in other brain regions
Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein.
organic cation transporter 3
, extraneuronal monoamine extraneuronal monoamine
, solute carrier family 22 member 3
, solute carrier family 22 (extraneuronal monoamine transporter), member 3
, solute carrier family 22, member 3
, EMT organic cation transporter 3
, extraneuronal monoamine transporter