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Structural component of the gap junctions and the hemichannels.. Additionally we are shipping Pannexin 3 Antibodies (25) and many more products for this protein.
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All three pannexins Panx1 (show PANX1 Proteins), Panx2 (show PANX2 Proteins), and Panx3 mRNAs were expressed in all of the analyzed undifferentiated stem cell lines.
Panx3 was upregulated during osteogenic differentiation in a time-dependent manner. Panx3 overexpression promoted osteogenic differentiation of human dental pulp-derived mesenchymal stromal cells, whereas depletion of Panx3 resulted in a decline of differentiation.
Panx3 channels regulate the proliferation, differentiation, and fusion of skeletal muscle myoblasts. (Review)
Panx3 has a defensive role in dental pulp inflammation.
The results of this study do not support a major contribution of PANX1 (show PANX1 Proteins)-3 to disease risk of schizophrenia according to DSM-5.
Case Report: osteosarcomatous transformation of axillary sweat gland neoplasm with high PANX3 expression.
Panx3 hemichannel is expressed in human odontoblast-like cells and mediates ATP release into the extracellular space.
Panx1 (show PANX1 Proteins) and Panx3 are co-expressed in human skeletal muscle myoblasts and play a pivotal role in dictating the proliferation and differentiation.
Data suggest that both up-regulation and down-regulation of expression of pannexins (PANX1 (show PANX1 Proteins), PANX2 (show PANX2 Proteins), PANX3) are associated with disease onset and/or progression; examples include neoplasms, multiple sclerosis, migraine, and hypertension. [REVIEW]
The 70 kDa immunoreactive species of Panx3 highly regulated during keratinocyte differentiation was shown to most likely correspond to another Panx3 isoform.
Panx3 modulates intracellular ATP levels, resulting in the inhibition of odontoblast proliferation through the AMPK (show PRKAA1 Proteins)/p21 signaling pathway and promotion of cell differentiation by the BMP/Smad (show SMAD1 Proteins) signaling pathway.
data suggest that Panx1 (show PANX1 Proteins) and Panx3 are not essential for baseline hearing in mice tested, but the therapeutic targeting of Panx3 may prove protective against mid-high-frequency hearing loss caused by loud NE.
The study has identified several genetic loci that influence both body mass index and carcinogenesis and implicate Panx3 as a candidate gene that links these phenotypes through its effects on inflammation and lipid metabolism.
Our results clearly show that Panx3 ablation produces phenotypic effects in mouse femora and humeri, and support the premise that Panx3 has a role in regulating long bone growth and development.
Panx3 functions as an endoplasmic reticulum (ER) Ca(2 (show CA2 Proteins)+) channel to promote differentiation, and it could rescue mineralization defects in Cx43 (show GJA1 Proteins)(-/-) calvarial cells.
Mice lacking Panx3 are resistant to the development of osteoarthritis.
results provide evidence of the crucial roles of Panx3 in vertebrate skeletal development in vivo.
Panx3 is a new regulator that promotes the switch from proliferation to differentiation of osteoprogenitors via multiple Panx3 signaling pathways.
Panx3 may serve an important role in bone development, and is a novel target for Runx2 (show RUNX2 Proteins)-dependent signaling.
Panx3 promotes osteoblast differentiation by functioning as an ER Ca(2 (show CA2 Proteins)+) channel and a hemichannel, and by forming gap junctions.
Structural component of the gap junctions and the hemichannels.
, pannexin 3
, gap junction protein pannexin 3