Polymerase (RNA) Mitochondrial (DNA Directed) Proteins (POLRMT)

POLRMT encodes a mitochondrial DNA-directed RNA polymerase. Additionally we are shipping POLRMT Antibodies (20) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat POLRMT POLRMT 299604  
POLRMT 5442 O00411
POLRMT 216151 Q8BKF1
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top POLRMT Proteins at antibodies-online.com

Showing 3 out of 4 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 70 Days
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days

POLRMT Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
Mouse (Murine)

More Proteins for Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) Interaction Partners

Human Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) interaction partners

  1. the frequency of variation in sequence identity and length at conserved sequence block 2 amongst human mitochondrial genomes and used in vitro transcription to assess the effects of this length heterogeneity on the activity of the mitochondrial RNA polymerase, POLRMT, was examined.

  2. Suggest targeting POLRMT as strategy for treating acute myeloid leukemia (show BCL11A Proteins).

  3. knock-down of MRPL12 (show MRPL12 Proteins) by RNA interference results in instability of POLRMT.

  4. Results show that polymorphisms at POLG2 (show POLG2 Proteins) and POLRMT increased risk of oral cancer and leukoplakia, respectively, probably modulating synthesis and activity of the enzymes.

  5. The results reveal the organization of TFAM (show TFAM Proteins), POLRMT and TFB2M (show TFB2M Proteins) around the light-strand promoter and represent the first structural characterization of the entire mitochondrial transcriptional initiation complex.

  6. The results demonstrate that human TFAM (show TFAM Proteins) binds to the N-terminal domain of mtRNAP, which results in bending of the promoter DNA around mtRNAP.

  7. Newly synthesized RNA exits toward the pentatricopeptide repeat (PPR (show PTH1R Proteins)) domain, a unique feature of mtRNAP with conserved RNA-recognition motifs.

  8. Authors propose that POLRMT interacts directly with h-mtTFB1 (show TFB1M Proteins) in 28S mitochondrial ribosomes to augment its 12S rRNA methyltransferase activity.

  9. X-ray structure of human mtRNAP at 2.5 A resolution, which reveals a T7-like catalytic carboxy-terminal domain, an amino-terminal domain resembling the T7 promoter-binding domain, a novel pentatricopeptide repeat domain, and flexible N-terminal extension

  10. muscle actin genes are transcribed by nuclear isoform of mitochondrial RNA polymerase (spRNAP-IV) whereas the non-muscle actin genes are transcribed by the conventional RNA polymerase II (PolII)

Mouse (Murine) Polymerase (RNA) Mitochondrial (DNA Directed) (POLRMT) interaction partners

  1. we present in vivo evidence that POLRMT has a key regulatory role in the replication of mammalian mtDNA and is part of a transcriptional mechanism that provides a switch between primer formation for mtDNA replication and mitochondrial gene expression.

  2. POLRMT recognizes promoter elements in a sequence specific manner; TFAM (show TFAM Proteins) induces a structural change of the promoter that is required for POLRMT-dependent promoter recognition

POLRMT Protein Profile

Protein Summary

This gene encodes a mitochondrial DNA-directed RNA polymerase. The gene product is responsible for mitochondrial gene expression as well as for providing RNA primers for initiation of replication of the mitochondrial genome. Although this polypeptide has the same function as the three nuclear DNA-directed RNA polymerases, it is more closely related to RNA polymerases of phage and mitochondrial polymerases of lower eukaryotes.

Gene names and symbols associated with POLRMT

  • RNA polymerase mitochondrial (Polrmt)
  • polymerase (RNA) mitochondrial (DNA directed) L homeolog (polrmt.L)
  • polymerase (RNA) mitochondrial (DNA directed) (polrmt)
  • RNA polymerase mitochondrial (POLRMT)
  • polymerase (RNA) mitochondrial (DNA directed) (Polrmt)
  • 1110018N15Rik protein
  • 4932416K13 protein
  • APOLMT protein
  • h-mtRPOL protein
  • MTRNAP protein
  • mtRPO protein
  • MTRPOL protein
  • POLRMT protein
  • polrmt-a protein
  • si:dkeyp-74c5.5 protein
  • wu:fb73g10 protein

Protein level used designations for POLRMT

DNA-directed RNA polymerase, mitochondrial , polymerase (RNA) mitochondrial (DNA directed) , mitochondrial DNA-directed RNA polymerase , mtRPOL

299604 Rattus norvegicus
394312 Xenopus laevis
557066 Danio rerio
504757 Bos taurus
5442 Homo sapiens
216151 Mus musculus
Selected quality suppliers for POLRMT Proteins (POLRMT)
Did you look for something else?