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PCDH10 belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. Additionally we are shipping PCDH10 Antibodies (45) and PCDH10 Kits (1) and many more products for this protein.
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PCDH10 hypermethylation were found in 54.2% (58/107) of DLBCL cases, but only 12.5% (1/8) in reactive lymph node/follicular hyperplasia.
This study provides insights into the tumorigenesis and progression of hepatocellular carcinoma (HCC (show FAM126A Proteins)), and puts forward the novel hypothesis that PCDH10 could be a new biomarker for HCC (show FAM126A Proteins), or that combined with other molecular markers could increase the specificity and sensitivity of diagnostic tests for HCC (show FAM126A Proteins). Restoration of PCDH10 could be a valuable therapeutic target for HCC (show FAM126A Proteins).
we found that the malignant character of GISTs was initiated and amplified by PCDH10 in a process regulated by HOTAIR. In summary, our findings imply that PCDH10 and HOTAIR may be useful markers of disease progression and therapeutic targets.
we found that long noncoding RNA (lncRNA) MALAT1 binds EZH2, suppresses the tumor suppressor PCDH10, and promotes gastric cellular migration and invasion
These findings suggest that Pcdh10 may influence subcellular actin cytoskeletal organization and axon-axon interactions in the course of familial amyloidotic polyneuropathy
PCDH10 methylation in serum is a potential prognostic biomarker for prostate cancer.
Study found that hypermethylation of CpG probes in the promoter regions of HOXA9 and PCDH10 was associated with mature B-cell neoplasms.
Results suggest that protocadherin 10 (PCDH10)-Dishevelled, EGL-10 and Pleckstrin domain containing 1 (DEPDC1)-caspase signaling may be a novel regulatory axis in endometrial endometrioid carcinoma (EEC) development.
Data show that protocadherin 10 (PCDH10) over-expression could significantly induce cell apoptosis, and restrain proliferation, invasion and migration ability of BXPC-3 pancreatic cancer cells.
Our present findings suggested that the hypermethylated CpG site counts of PCDH10 DNA promoter for evaluating the prognosis of GC was reasonable by using the D-BGS
male Pcdh10(+/-) mice exhibited reduced gamma-band (30-80Hz), but not lower frequency (10 and 20Hz), auditory steady state responses (ASSR). In addition, male Pcdh10(+/-) mice exhibited decreased signal-to-noise-ratio (SNR) for high gamma-band (60-100Hz) activity. Administration of a GABAB agonist remediated these electrophysiological alterations among male Pcdh10(+/-)mice.
Studies reveals that male Pcdh10(+/-) mice have synaptic and behavioral deficits, and establish Pcdh10(+/-) mice as a novel genetic model for investigating neural circuitry and behavioral changes relevant to autism spectrum disorder.
Pcdh10, which is regulated by Pou3f1 (show POU3F1 Proteins) and Hoxa5 (show HOXA5 Proteins), is a mediator of like-like clustering of motor neuron cell bodies in the developing phrenic nerve.
results show that OL-pc is essential for both elongation of striatal axons and patterning of the putative guidance cues for thalamocortical projections.
The role of OL-protocadherin-dependent striatal axon growth in neural circuit formation.
This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. The mRNA encodes a cadherin-related neuronal receptor thought to play a role in the establishment and function of specific cell-cell connections in the brain. This family member contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical cadherins. Alternatively spliced transcripts encode isoforms with unique cytoplasmic domains.
ortholog of OL-pcdh
, protocadherin 10
, OL-protocadherin isoform