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PCDHGC3 is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. Additionally we are shipping Protocadherin gamma Subfamily C, 3 Antibodies (162) and and many more products for this protein.
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our data suggest that the PCDH LRES is an important tumour suppressor locus in colorectal cancer, and that PCDHGC3 may be a strong marker and driver for the adenoma-carcinoma transition.
ADAM10 is the protease responsible for constitutive and regulated Pcdh gamma shedding events that modulate the cell adhesion role of Pcdh gamma.
The results of this study reveal a distinct role for the gamma-Pcdhs in cortical development and identify a signaling pathway through which they play this role.
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.
, protocadherin 2
, protocadherin 43
, protocadherin gamma-C3
, protocadherin gamma subfamily A, 11
, protocadherin gamma subfamily C, 5