Ras Homolog Gene Family, Member T2 Proteins (RHOT2)

RHOT2 encodes a member of the Rho family of GTPases. Additionally we are shipping Ras Homolog Gene Family, Member T2 Antibodies (38) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
RHOT2 89941 Q8IXI1
Rat RHOT2 RHOT2 287156 Q7TSA0
RHOT2 214952 Q8JZN7
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Top Ras Homolog Gene Family, Member T2 Proteins at antibodies-online.com

Showing 4 out of 7 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 50 to 55 Days
$7,626.01
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details

RHOT2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, , ,
Mouse (Murine)
,

More Proteins for Ras Homolog Gene Family, Member T2 (RHOT2) Interaction Partners

Human Ras Homolog Gene Family, Member T2 (RHOT2) interaction partners

  1. Show that the C-terminal GTPase of the Parkin primary substrates Miro1 and Miro2 are necessary and sufficient for efficient ubiquitination. We present several new X-ray crystal structures of both Miro1 and Miro2 that reveal substrate recognition and ubiquitin transfer to be specific to particular protein domains and lysine residues.

  2. Miro and Cenp-F (show CENPF Proteins) promote anterograde mitochondrial movement and proper mitochondrial distribution in daughter cells.

  3. The Miro2-mediated mitochondrial transport in neurons and recently highlighted involvement of Miro2 proteins in mitochondrial turnover, emerging as a key process affected in neurodegeneration.

  4. Study shows that both PINK1 (show PINK1 Proteins) and Parkin (show PARK2 Proteins) halt mitochondrial movement; PINK1 (show PINK1 Proteins) phosphorylates Miro (1 (show RHOT1 Proteins) and 2) and thereby initiates the rapid degradation of Miro through a Parkin (show PARK2 Proteins)- and proteasome-dependent pathway.

  5. Moreover, we show that Miro interacts with the Kinesin-binding proteins, GRIF-1 and OIP106 (show TRAK1 Proteins), suggesting that the Miro GTPases form a link between the mitochondria and the trafficking apparatus of the microtubules.

  6. Miro proteins serve as a [Ca(2 (show CA2 Proteins)+)](c)-sensitive switch and bifunctional regulator for both the motility and fusion-fission dynamics of the mitochondria.

Mouse (Murine) Ras Homolog Gene Family, Member T2 (RHOT2) interaction partners

  1. both Miro proteins can act to coordinate microtubule-dependent and actin-dependent mitochondrial trafficking, Miro1 (show RHOT1 Proteins) preferentially acts to control microtubule-dependent trafficking through kinesin and dynein, while Miro2 plays a more prominent role in coordinating mitochondrial interactions with the actin cytoskeleton through a more efficient recruitment and stability of endogenous Myo19 (show MYO19 Proteins) in the mitochondrial membrane.

  2. Using mouse knockout strategies, we demonstrate that Miro1 (show RHOT1 Proteins), as opposed to Miro2, is the primary regulator of mitochondrial transport in both axons and dendrites. Miro1 (show RHOT1 Proteins) deletion leads to depletion of mitochondria from distal dendrites but not axons, accompanied by a marked reduction in dendritic complexity. Disrupting postnatal mitochondrial distribution in vivo by deleting Miro1 (show RHOT1 Proteins) in mature neurons causes a progressive loss

  3. Armcx genes regulate mitochondrial trafficking in neurons and interact with Miro 1/2 and Trak2.

  4. molecular cloning and characterization of a novel mouse cDNA encoding a putative atypical GTPase (show RACGAP1 Proteins) protein, Arht2

Ras Homolog Gene Family, Member T2 (RHOT2) Protein Profile

Protein Summary

This gene encodes a member of the Rho family of GTPases. The encoded protein is localized to the outer mitochondrial membrane and plays a role in mitochondrial trafficking and fusion-fission dynamics.

Gene names and symbols associated with RHOT2

  • ras homolog family member T2 (RHOT2)
  • ras homolog family member T2 (Rhot2)
  • ras homolog family member T2 (rhot2)
  • Arht2 protein
  • C16orf39 protein
  • DKFZp459P0951 protein
  • MIRO-2 protein
  • Miro2 protein
  • RASL protein
  • RHOT2 protein
  • zgc:123249 protein

Protein level used designations for RHOT2

ras homolog gene family, member T2 , mitochondrial Rho GTPase 2-like , mitochondrial Rho (MIRO) GTPase 2 , mitochondrial Rho GTPase 2 , MIRO-2 , miro protein , mitochondrial Rho 2 , ras homolog gene family member T2 , rho GTPase

GENE ID SPECIES
453800 Pan troglodytes
479893 Canis lupus familiaris
100066937 Equus caballus
100294664 Pongo abelii
100395876 Callithrix jacchus
89941 Homo sapiens
287156 Rattus norvegicus
352959 Bos taurus
427651 Gallus gallus
397596 Sus scrofa
214952 Mus musculus
557574 Danio rerio
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