anti-Runt-Related Transcription Factor 2 (RUNX2) Antibodies

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain.

list all antibodies Gene Name GeneID UniProt
Anti-Human RUNX2 RUNX2 860 Q13950
Anti-Mouse RUNX2 RUNX2 12393 Q08775
Anti-Rat RUNX2 RUNX2 367218  
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Top anti-RUNX2 Antibodies at antibodies-online.com

Showing 10 out of 248 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate RUNX2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells WB Suggested Anti-RUNX2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control:.21_B cell lysate <br /> RUNX2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated EMSA AML-3/Runx2 pAb tested by supershift. Detection of AML-3/Runx2 by EMSA analysis. AML-3/Runx2 pAb was used in a supershift assay (EMSA) with Saos-2 nuclear extract (lane 4). 100 μL Log in to see 1 to 2 Days
$495.83
Details
Human Rabbit Un-conjugated WB Observed bind size: 62KD Anti-RUNX2 Picoband antibody,  All lanes: Anti RUNX2  at 0.5ug/ml WB: Recombinant Human RUNX2 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:2500  Positive Control:  HepG2 cell lysate Sample Type: Lane 1:241 µg mouse mesenchymal stem cell lysate <br />Primary Antibody Dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:00,000 Color/Signal Descriptions: RUNX2 <br /> Gene Name: Anonymous <br /><br />Submitted by: 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p), WB Western Blot: RUNX2 Antibody [NBP1-89104] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp Immunocytochemistry/Immunofluorescence: RUNX2 Antibody [NBP1-89104] - Staining of human cell line U-2 OS shows positivity in nuclei but not nucleoli. 0.1 mL Log in to see 10 to 13 Days
$491.63
Details
Human Rabbit Un-conjugated WB Anti-RUNX2 antibody, Western blotting Lane 1: Rat Thymus Tissue Lysate Lane 2: Rat Testis Tissue Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Runx2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Rat Liver WB Suggested Anti-Runx2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Rat Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated DB Dot blot analysis of anti-Phospho-RUNX2-S533 Antibody (ABIN389942) on nitrocellulose membrane.  50 ng of Phospho-peptide or Non Phospho-peptide per dot were adsorbed. Antibody working concentrations are 0.5 µg/mL. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate Host:  Rabbit  Target Name:  RUNX2  Sample Tissue:  Human Jurkat  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details

Top referenced anti-RUNX2 Antibodies

  1. Human Polyclonal RUNX2 Primary Antibody for DB - ABIN389942 : McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: Skeletal stem cell physiology on functionally distinct titania nanotopographies. in Biomaterials 2011 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043708 : Li, Chen, Peng, Zhou, Fang: Pulsed electromagnetic fields protect the balance between adipogenesis and osteogenesis on steroid-induced osteonecrosis of femoral head at the pre-collapse stage in rats. in Bioelectromagnetics 2014 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043428 : Wang, Mu, Fan, Yu, Yan, Lei, Tang, Wang, Zheng, Yu, Zhang: Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. in Stem cell research 2012 (PubMed)
    Show all 6 Pubmed References

  4. Human Polyclonal RUNX2 Primary Antibody for EMSA - ABIN3434043 : Huang, Xie, Konaka, Sodek, Zhau, Chung: Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway. in Cancer research 2005 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal RUNX2 Primary Antibody for IF, IHC (p) - ABIN514045 : Wang, Li, Li, Yang, Sasaki, Wang, Zhou, Araki, Mezawa, Takai, Ogata: Effects of inorganic polyphosphate on bone sialoprotein gene expression. in Gene 2010 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351437 : Mao, Shin, Mooney: Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation. in Biomaterials 2016 (PubMed)
    Show all 5 Pubmed References

  7. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351441 : Martínez-Abadías, Holmes, Pankratz, Wang, Zhou, Jabs, Richtsmeier: From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome. in Disease models & mechanisms 2013 (PubMed)
    Show all 3 Pubmed References

  8. Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2780588 : Lee, Lee, Ryoo, Park, Park, Bae, Cho, Park: The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20. in Journal of cellular biochemistry 2010 (PubMed)
    Show all 2 Pubmed References

  9. Human Monoclonal RUNX2 Primary Antibody for IF, IHC (p) - ABIN560185 : Sase, Suzuki, Miura, Shiiba, Sato, Nakamura, Takagi, Onodera, Miki, Watanabe, Ishida, Ohnuma, Sasaki, Sato, Karasawa, Shibata, Unno, Sasaki, Sasano: Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351459 : Mao, Shin, Utech, Wang, Uzun, Li, Cooper, Hu, Zhang, Weitz, Mooney: Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery. in Nature materials 2016 (PubMed)
    Show all 2 Pubmed References

More Antibodies against RUNX2 Interaction Partners

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Results identified a novel mutation besides the previously known in one patient with cleidocranial dysplasia (CCD). G462X mutation in exon 8 is located in the C-terminus of proline/serine/threonine-rich (PST (show SULT1A1 Antibodies)) domain. It might reduce the Runx2 transacting activity, lower the protein stability, downgrade the expression of bone marker genes, and eventually diminish osteoblast differentiation in CCD patients.

  2. Findings reveal a novel mechanism that Runx2 is transcriptionally regulated by HSP90 (show HSP90 Antibodies) via the AKT (show AKT1 Antibodies)/GSK-3beta/beta-catenin (show CTNNB1 Antibodies) signaling pathway, and by which leads to apoptosis of osteosarcoma cells.

  3. Increased baseline gene expressions of RUNX2, p21 (show CDKN1A Antibodies) and caspase 3 (show CASP3 Antibodies) in the peripheral blood might predict better responses to methotrexate therapy.

  4. Study identifies a novel missense mutation (c.895 T>C, Y299H) in exon 5 of Runx2 gene in patients with cleidocranial dysplasia (CCD). This mutation results in an amino acid change at codon 895 (P.Tyr 299 His.) from a tryptophan codon (TAT (show TAT Antibodies)) to a histidine codon (CAT).

  5. miR (show MLXIP Antibodies)-539 functions as a tumor suppressor in colorectal cance, at least in part, by targeting RUNX2.

  6. These results indicate activation of DLX5 (show DLX5 Antibodies) and RUNX2 via its distal promoter represents a unique feature of GFs, and is important for ECM (show MMRN1 Antibodies) regulation. Down-regulation of these transcription factors in PAFs could be associated with their property to degrade collagen, which may impact on the process of periodontitis.

  7. down-regulated miR (show MLXIP Antibodies)-143-5p promotes the differentiation of DPSCs into odontoblasts by enhancing Runx2 expression via the OPG/RANKL (show TNFSF11 Antibodies) signaling pathway.

  8. The Runx2 is one of the genes responsible for the pathogenesis of osteoarthritis (OA) because RUNX2 is up-regulated in chondrocytes in OA cartilage and a germline haplodeficiency or deletion of Runx2 in articular chondrocytes decelerates OA progression.

  9. application of dexamethasone reduced the expression of RUNX2 and beta-catenin (show CTNNB1 Antibodies) in human gingiva-derived mesenchymal stem cells

  10. Runt-related transcription factor 2 (RUNX2) was directly negatively regulated by miR (show MLXIP Antibodies)-203.

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Puerarin may promote MC3T3E1 osteoblastlike cell viability and differentiation, which may be related to the downregulation of miR204 and the following activation of Runx2.

  2. mTOR (show FRAP1 Antibodies)/Raptor (show RPTOR Antibodies) signaling is essential for bone formation in vivo through the regulation of Runx2 expression.

  3. these findings provide evidence that Cx43 (show GJA1 Antibodies) and Runx2 functionally intersect in vivo to regulate cortical bone properties and affect osteoblast differentiation and proliferation

  4. miR (show MLXIP Antibodies)-133a-5p targets the 3' UTR (show UTS2R Antibodies) of RUNX2 mRNA to regulate the expression of RUNX2 negatively.

  5. muramyl dipeptide directly augmented osteoblast differentiation and bone-forming gene expression by Runx2 activation.

  6. Loss of Runx1 (show RUNX1 Antibodies) and Runx2 inhibits prostate cell motility.

  7. fetal administration of Entinostat/MS-275, a class I histone deacetylase (HDAC (show HDAC1 Antibodies))-specific inhibitor, partially prevents delayed closure of cranial sutures in Runx2(+/-) mice strain of C57BL/6J by two mechanisms: 1) posttranslational acetylation of Runx2 protein, which stabilized the protein and activated its transcriptional activity; and 2) epigenetic regulation of Runx2 and other bone marker genes

  8. These data suggest that NaF (show IL8 Antibodies) promotes the osteoblastic differentiation of MC3T3-E1 cells through the Runx2/Osterix (show SP7 Antibodies) pathway and may be effective for the treatment of bone-related disorders.

  9. results suggest that Edil3 may stimulate osteoblast differentiation and matrix mineralization by increasing expression of Runx2 through alpha5beta1 integrin /ERK (show EPHB2 Antibodies) pathway

  10. Taken together, these results demonstrate that piperine enhance osteoblast differentiation through AMPK (show PRKAA1 Antibodies) phosphorylation in MC3T3-E1 cells.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG (show TNFSF11 Antibodies) expression levels decreased while those of RANKL (show TNFSF11 Antibodies) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP (show MGP Antibodies) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Klotho (show KL Antibodies) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 pathway.

RUNX2 Antigen Profile

Protein Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt related transcription factor 2 (RUNX2) antibody
  • runt-related transcription factor 2a (runx2a) antibody
  • runt related transcription factor 2 (Runx2) antibody
  • runt-related transcription factor 2 (Runx2) antibody
  • runt related transcription factor 2 (runx2) antibody
  • runt-related transcription factor 2 (LOC703331) antibody
  • runt-related transcription factor 2 (LOC100549663) antibody
  • runt related transcription factor 2 L homeolog (runx2.L) antibody
  • runt-related transcription factor 2 (RUNX2) antibody
  • aml3 antibody
  • Cbf antibody
  • CBF-alpha-1 antibody
  • Cbfa-1 antibody
  • cbfa1 antibody
  • ccd antibody
  • ccd1 antibody
  • CLCD antibody
  • LS3 antibody
  • OSF-2 antibody
  • osf2 antibody
  • pea2aa antibody
  • pebp2a1 antibody
  • pebp2a2 antibody
  • pebp2aa antibody
  • pebp2aa1 antibody
  • Pebpa2a antibody
  • RUNX2 antibody

Protein level used designations for RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

GENE ID SPECIES
860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
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