anti-Runt-Related Transcription Factor 2 (RUNX2) Antibodies

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Kits (49) and RUNX2 Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX2 860 Q13950
RUNX2 12393 Q08775
RUNX2 367218  
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Top anti-RUNX2 Antibodies at antibodies-online.com

Showing 10 out of 239 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>721_B cell lysate WB Suggested Anti-RUNX2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control:.21_B cell lysate <br /> RUNX2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:2500<br><b>Positive Control: </b>HepG2 cell lysate Sample Type: Lane 1:241 µg mouse mesenchymal stem cell lysate <br />Primary Antibody Dilution: 1:0000<br />Secondary Antibody: Anti-rabbit-HRP <br />Secondary Antibody Dilution: 1:00,000 Color/Signal Descriptions: RUNX2 <br /> Gene Name: Anonymous <br /><br />Submitted by: 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX2 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:1562500<br><b>Positive Control: </b>Jurkat cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-RUNX2 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details
Cow Rabbit Un-conjugated WB <b>WB Suggested Anti-Runx2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Rat Liver WB Suggested Anti-Runx2 <br /> Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500 <br /> Positive Control: Rat Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB Observed bind size: 62KD Anti-RUNX2 Picoband antibody,  All lanes: Anti RUNX2  at 0.5ug/ml WB: Recombinant Human RUNX2 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated EIA 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Chicken Rabbit Un-conjugated IHC, WB Immunohistochemical analysis of RUNX2 staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. Western blot analysis of RUNX2 expression in Saos2 (A), HepG2 (B), Jurkat (C) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details
Human Rabbit Un-conjugated WB Anti-RUNX2 antibody, Western blotting Lane 1: Rat Thymus Tissue Lysate Lane 2: Rat Testis Tissue Lysate 100 μg Log in to see 4 to 6 Days
$200.00
Details
Human Rabbit Un-conjugated WB Western blot analysis of RUNX2 expression in K562 (A), Hela (B) whole cell lysates. 200 μL Log in to see 13 to 14 Days
$487.50
Details

RUNX2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-RUNX2 Antibodies

  1. Human Polyclonal RUNX2 Primary Antibody for DB - ABIN389942 : McNamara, Sjöström, Burgess, Kim, Liu, Gordonov, Moghe, Meek, Oreffo, Su, Dalby: Skeletal stem cell physiology on functionally distinct titania nanotopographies. in Biomaterials 2011 (PubMed)
    Show all 8 Pubmed References

  2. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043708 : Li, Chen, Peng, Zhou, Fang: Pulsed electromagnetic fields protect the balance between adipogenesis and osteogenesis on steroid-induced osteonecrosis of femoral head at the pre-collapse stage in rats. in Bioelectromagnetics 2014 (PubMed)
    Show all 6 Pubmed References

  3. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043428 : Wang, Mu, Fan, Yu, Yan, Lei, Tang, Wang, Zheng, Yu, Zhang: Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. in Stem cell research 2012 (PubMed)
    Show all 6 Pubmed References

  4. Human Polyclonal RUNX2 Primary Antibody for EMSA - ABIN3434043 : Huang, Xie, Konaka, Sodek, Zhau, Chung: Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway. in Cancer research 2005 (PubMed)
    Show all 5 Pubmed References

  5. Human Monoclonal RUNX2 Primary Antibody for IF, IHC (p) - ABIN514045 : Wang, Li, Li, Yang, Sasaki, Wang, Zhou, Araki, Mezawa, Takai, Ogata: Effects of inorganic polyphosphate on bone sialoprotein gene expression. in Gene 2010 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351437 : Mao, Shin, Mooney: Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation. in Biomaterials 2016 (PubMed)
    Show all 4 Pubmed References

  7. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351441 : Martínez-Abadías, Holmes, Pankratz, Wang, Zhou, Jabs, Richtsmeier: From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome. in Disease models & mechanisms 2013 (PubMed)
    Show all 3 Pubmed References

  8. Human Monoclonal RUNX2 Primary Antibody for IF, IHC (p) - ABIN560185 : Sase, Suzuki, Miura, Shiiba, Sato, Nakamura, Takagi, Onodera, Miki, Watanabe, Ishida, Ohnuma, Sasaki, Sato, Karasawa, Shibata, Unno, Sasaki, Sasano: Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor. in International journal of cancer. Journal international du cancer 2012 (PubMed)
    Show all 2 Pubmed References

  9. Cow (Bovine) Polyclonal RUNX2 Primary Antibody for WB - ABIN2780588 : Lee, Lee, Ryoo, Park, Park, Bae, Cho, Park: The odontogenic ameloblast-associated protein (ODAM) cooperates with RUNX2 and modulates enamel mineralization via regulation of MMP-20. in Journal of cellular biochemistry 2010 (PubMed)
    Show all 2 Pubmed References

  10. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351459 : Mao, Shin, Utech, Wang, Uzun, Li, Cooper, Hu, Zhang, Weitz, Mooney: Deterministic encapsulation of single cells in thin tunable microgels for niche modelling and therapeutic delivery. in Nature materials 2016 (PubMed)
    Show all 2 Pubmed References

More Antibodies against RUNX2 Interaction Partners

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. WWOX (show WWOX Antibodies) expression was strongly inhibited in human lung cancers and lung cancer cell lines. Reintroducing WWOX (show WWOX Antibodies) into lung cancer cells inhibited their invasive phenotype through downregulating RUNX2 and its target genes including MMP-9 (show MMP9 Antibodies) expression.

  2. our results strongly suggest that RUNX2 might be a key player in receptor tyrosine kinase (show RET Antibodies) (RTK)-based autocrine loops and a mediator of resistance to BRAF (show BRAF Antibodies) V600E inhibitors involving RTK up regulation in melanoma.

  3. Thus, WNT (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) activation is required for RUNX2 expression in at least some osteosarcoma cell types, where RUNX2 is known to promote expression of metastasis related genes.

  4. miR (show MLXIP Antibodies)-105/Runx2 axis mediates FGF2 (show FGF2 Antibodies)-induced ADAMTS (show ADAMTS13 Antibodies) expression in osteoarthritis cartilage.

  5. regulation of gal-3 (show LGALS3 Antibodies) expression was strongly correlated with runx2 transcription factor in human thyroid carcinoma.

  6. Studied association of runt-related transcription factor 2 (RUNX2) polymorphisms with susceptibility and prognosis of ossification of posterior longitudinal ligament.

  7. these studies define a novel fibrinogen-alpha9beta1-SMAD1 (show GARS Antibodies)/5/8-RUNX2 signaling axis can efficiently induce osteogenic differentiation from human embryonic stem cells and induced pluripotent stem cells.

  8. Data show that BRD4 (show BRD4 Antibodies) controls RUNX2 by binding to the enhancers (ENHs) and each RUNX2 ENH (show PDLIM5 Antibodies) is potentially controlled by a distinct set of TFs and c-JUN (show JUN Antibodies) as the principal pivot of this regulatory platform.

  9. TGF-beta1 (show TGFB1 Antibodies) stimulates the phosphorylation of Runx2 at three serine amino acids, and this event is required for MMP-13 (show MMP13 Antibodies) expression in osteoblastic cells.

  10. TP(thymidine phosphorylase (show TYMP Antibodies) ) curbed the expression of three proteins-IRF8 (show IRF8 Antibodies), RUNX2, and osterix (show SP7 Antibodies). This downregulation was epigenetically driven: High levels of 2DDR, a product of TP secreted by myeloma cells, activated PI3K (show PIK3CA Antibodies)/AKT (show AKT1 Antibodies) signaling and increased the methyltransferase DNMT3A's expression

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. results suggest that Edil3 may stimulate osteoblast differentiation and matrix mineralization by increasing expression of Runx2 through alpha5beta1 integrin /ERK (show EPHB2 Antibodies) pathway

  2. Taken together, these results demonstrate that piperine enhance osteoblast differentiation through AMPK (show PRKAA1 Antibodies) phosphorylation in MC3T3-E1 cells.

  3. Sphingosine 1 phosphate also up-regulated runt-related transcription factor 2 (Runx2) expression through S1PR2 (show S1PR2 Antibodies)/RhoA (show RHOA Antibodies)/ROCK/Smad1 (show SMAD1 Antibodies)/5/8 signaling.

  4. Nearly half of all DNase (show DNASE2 Antibodies) hypersensitivity sites (both constitutive and dynamic) overlap binding events of the bone-essential RUNX2 and/or the chromatin-related CTCF (show CTCF Antibodies) transcription factors.

  5. The findings suggest that the absence of uPA (show PLAU Antibodies) correlates with increased levels of Runx transcriptional regulators in a way that promotes inflammation-associated carcinogenesis.

  6. Fam50a (show FAM50A Antibodies) might be a new positive regulator of ameloblast differentiation, increasing binding affinity of Runx2 to Ambn (show AMBN Antibodies) promoter by physically interacting with Runx2.

  7. Knockdown of MACF1 (show MACF1 Antibodies) in osteoblastic cells inhibits osteoblast differentiation through suppressing the beta-catenin (show CTNNB1 Antibodies)/TCF1 (show HNF1A Antibodies)-Runx2 axis.

  8. These results suggest that Dietary methionine restriction (MR) alters bone remodeling and apposition. In MR mice, miR (show MLXIP Antibodies)-31 in plasma and liver, and miR (show MLXIP Antibodies)-133a, miR (show MLXIP Antibodies)-335-5p, and miR (show MLXIP Antibodies)-204 in the bone marrow was elevated. These miRNAs were shown previously to target and regulate Osterix (show SP7 Antibodies) and RUNX2 in bone, which could inhibit osteoblast differentiation and function.

  9. SIRT1 (show SIRT1 Antibodies) interacts with and promotes the transactivation potential of RUNX2.

  10. ABL (show ABL1 Antibodies) potentiated the assembly and activation of the RUNX2-TAZ (show TAZ Antibodies) master transcription factor complex that is required for osteoblastogenesis, while antagonizing PPARgamma (show PPARG Antibodies)-mediated adipogenesis.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG (show TNFSF11 Antibodies) expression levels decreased while those of RANKL (show TNFSF11 Antibodies) and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP (show MGP Antibodies) is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Klotho (show KL Antibodies) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Antibodies)-RUNX2 pathway.

RUNX2 Antigen Profile

Protein Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt related transcription factor 2 (RUNX2) antibody
  • runt-related transcription factor 2a (runx2a) antibody
  • runt related transcription factor 2 (Runx2) antibody
  • runt-related transcription factor 2 (Runx2) antibody
  • runt related transcription factor 2 (runx2) antibody
  • uncharacterized LOC449531 (LOC449531) antibody
  • runt-related transcription factor 2 (LOC703331) antibody
  • runt-related transcription factor 2 (LOC100549663) antibody
  • runt related transcription factor 2 L homeolog (runx2.L) antibody
  • runt-related transcription factor 2 (RUNX2) antibody
  • aml3 antibody
  • Cbf antibody
  • CBF-alpha-1 antibody
  • Cbfa-1 antibody
  • cbfa1 antibody
  • ccd antibody
  • ccd1 antibody
  • CLCD antibody
  • LS3 antibody
  • OSF-2 antibody
  • osf2 antibody
  • pea2aa antibody
  • pebp2a1 antibody
  • pebp2a2 antibody
  • pebp2aa antibody
  • pebp2aa1 antibody
  • Pebpa2a antibody
  • RUNX2 antibody

Protein level used designations for RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

GENE ID SPECIES
860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
449531 Canis lupus familiaris
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
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