anti-Runt-Related Transcription Factor 2 (RUNX2) Antibodies

RUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. Additionally we are shipping RUNX2 Kits (60) and RUNX2 Proteins (12) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX2 860 Q13950
RUNX2 12393 Q08775
RUNX2 367218  
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Top anti-RUNX2 Antibodies at antibodies-online.com

Showing 10 out of 242 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated WB Observed bind size: 62KD Anti-RUNX2 Picoband antibody,  All lanes: Anti RUNX2  at 0.5ug/ml WB: Recombinant Human RUNX2 Protein 0.5ng Predicted bind size: 50KD Observed bind size: 50KD 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IHC, WB   100 μL Log in to see 6 to 11 Days
$350.00
Details
Human Rabbit Un-conjugated WB Anti-RUNX2 antibody, Western blotting Lane 1: Rat Thymus Tissue Lysate Lane 2: Rat Testis Tissue Lysate 100 μg Log in to see 4 to 6 Days
$240.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  721_B cell lysate RUNX2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells WB Suggested Anti-RUNX2  Antibody Titration: 0.2-1 µg/mL ELISA Titer: 1:.12500  Positive Control:.21_B cell lysate  RUNX2 is strongly supported by BioGPS gene expression data to be expressed in Human 721_B cells 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:2500  Positive Control:  HepG2 cell lysate Sample Type: Lane 1:241 µg mouse mesenchymal stem cell lysate Primary Antibody Dilution: 1:0000Secondary Antibody: Anti-rabbit-HRP Secondary Antibody Dilution: 1:00,000 Color/Signal Descriptions: RUNX2  Gene Name: Anonymous Submitted by: 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-Runx2 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  Rat Liver 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:1562500  Positive Control:  Jurkat cell lysate Host:  Rabbit  Target Name:  RUNX2  Sample Tissue:  Human Jurkat  Antibody Dilution:  1.0ug/ml 100 μL Log in to see 2 to 3 Days
$249.00
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of OS-RC-2 cell lines, using RUNX2 antibody. Western blot analysis of extracts of various cell lines, using RUNX2 antibody. 100 μL Log in to see 13 to 14 Days
$393.25
Details
Human Rabbit Un-conjugated ICC, IF, IHC, IHC (p) Immunocytochemistry/Immunofluorescence: RUNX2/CBFA1 Antibody [NBP1-77461] - RUNX2 antibody was tested in HeLa cells with FITC (green). Nuclei and alpha-tubulin were counterstained with Dapi (blue) and Dylight 550 (red). Immunohistochemistry: RUNX2/CBFA1 Antibody [NBP1-77461] - Staining of RUNX2 in mouse prostate using DAB with hematoxylin counterstain. 0.1 mL Log in to see 7 to 9 Days
$446.35
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX2 Antibody Titration:  1.25ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate 100 μL Log in to see 2 to 3 Days
$229.00
Details

Top referenced anti-RUNX2 Antibodies

  1. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043428 : Li, Chen, Peng, Zhou, Fang: Pulsed electromagnetic fields protect the balance between adipogenesis and osteogenesis on steroid-induced osteonecrosis of femoral head at the pre-collapse stage in rats. in Bioelectromagnetics 2014 (PubMed)
    Show all 9 Pubmed References

  2. Human Polyclonal RUNX2 Primary Antibody for WB - ABIN3043708 : Wang, Mu, Fan, Yu, Yan, Lei, Tang, Wang, Zheng, Yu, Zhang: Insulin-like growth factor 1 can promote the osteogenic differentiation and osteogenesis of stem cells from apical papilla. in Stem cell research 2012 (PubMed)
    Show all 8 Pubmed References

  3. Human Polyclonal RUNX2 Primary Antibody for IHC, WB - ABIN6711440 : Zhao, Zhang, Zeng, Xia, Lamichhane, Jiang, Zhang: rhPDGF-BB promotes proliferation and osteogenic differentiation of bone marrow stromal cells from streptozotocin-induced diabetic rats through ERK pathway. in BioMed research international 2014 (PubMed)
    Show all 8 Pubmed References

  4. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351437 : Mao, Shin, Mooney: Effects of substrate stiffness and cell-cell contact on mesenchymal stem cell differentiation. in Biomaterials 2016 (PubMed)
    Show all 6 Pubmed References

  5. Human Monoclonal RUNX2 Primary Antibody for IF, IHC (p) - ABIN514045 : Wang, Li, Li, Yang, Sasaki, Wang, Zhou, Araki, Mezawa, Takai, Ogata: Effects of inorganic polyphosphate on bone sialoprotein gene expression. in Gene 2010 (PubMed)
    Show all 5 Pubmed References

  6. Human Polyclonal RUNX2 Primary Antibody for IHC, WB - ABIN6670409 : Wang, Zhang, Sun, Wang, Yang, Yang, Zhang, Luo, Wang, Jiang, Zeng, Cai, Bai: Intra-articular Delivery of Antago-miR-483-5p Inhibits Osteoarthritis by Modulating Matrilin 3 and Tissue Inhibitor of Metalloproteinase 2. in Molecular therapy : the journal of the American Society of Gene Therapy 2017 (PubMed)
    Show all 5 Pubmed References

  7. Human Polyclonal RUNX2 Primary Antibody for EMSA - ABIN3434043 : Huang, Xie, Konaka, Sodek, Zhau, Chung: Human osteocalcin and bone sialoprotein mediating osteomimicry of prostate cancer cells: role of cAMP-dependent protein kinase A signaling pathway. in Cancer research 2005 (PubMed)
    Show all 5 Pubmed References

  8. Human Polyclonal RUNX2 Primary Antibody for IHC, WB - ABIN3016834 : Zhang, Wang, Zeng, Yan, Ouyang, Liu, Sun, Zhao, Fang, Pan, Xie, Yang, Zhang, Bai, Cai: mTORC1 activation downregulates FGFR3 and PTH/PTHrP receptor in articular chondrocytes to initiate osteoarthritis. in Osteoarthritis and cartilage 2018 (PubMed)
    Show all 5 Pubmed References

  9. Human Polyclonal RUNX2 Primary Antibody for ICC, IF - ABIN4351441 : Martínez-Abadías, Holmes, Pankratz, Wang, Zhou, Jabs, Richtsmeier: From shape to cells: mouse models reveal mechanisms altering palate development in Apert syndrome. in Disease models & mechanisms 2013 (PubMed)
    Show all 3 Pubmed References

  10. Polyclonal RUNX2 Primary Antibody for IHC (p), WB - ABIN540597 : DSouza, Aberg, Gaikwad, Cavender, Owen, Karsenty, Thesleff: Cbfa1 is required for epithelial-mesenchymal interactions regulating tooth development in mice. in Development (Cambridge, England) 1999 (PubMed)
    Show all 3 Pubmed References

More Antibodies against RUNX2 Interaction Partners

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. DGCR5 negatively regulates miR-30d-5p, and it up-regulates Runx2 through miR-30d-5p, thereby inducing osteogenic differentiation of hMSCs, which may help to delay Postmenopausal osteoporosis development.

  2. MiR-223 and miR-19a were found to regulate the expression of TWIST and Runx2, influence the RANKL-RANK pathway and the expression of MCP-1, and finally regulate the pathophysiological process of osteolytic bone destruction.

  3. lncRNA TUG1 acts as a miR-204-5p sponge in aortic valve calcification, promoting osteoblast differentiation by upregulating Runx2 expression.

  4. Study demonstrates that the plasmacytoid dendritic cells (pDCs)-specific RUNX2 super-enhancer is hijacked to activate expression of MYC via t(6;8) in blastic plasmacytoid dendritic cell neoplasm (BPDCN) cells, and unveil the molecular mechanisms underlying the pathogenesis of BPDCN, which originates from a precursor of pDCs.

  5. Intragenic duplication of RUNX2 was found in three family members affected with metaphyseal dysplasia with maxillary hypoplasia and brachydactyly.

  6. PARP1 promotes Runx2 expression, and Runx2 deficiency offsets the pro-calcifying effects of PARP1. Activated PARP1 suppresses miRNA-204 expression via the IL-6/STAT3 pathway and thus relieves the repression of its target, Runx2, resulting in increased Runx2 protein.

  7. The lncRNA SNHG20/miR-139/RUNX2 axis modulates the osteosarcoma tumorigenesis and apoptosis via mitochondrial apoptosis pathway, providing a novel insight for the pathophysiological process.

  8. Here, genotype at an Osteoarthritis (OA) risk locus correlates with differential DNA methylation, with altered gene expression of both a transcriptional regulator (RUNX2), and a chromatin remodelling protein (SUPT3H).

  9. Study results suggest a role for CAV1 down-regulation in linking the aberrant responsiveness to mechanical stimulation and extracellular matrix accumulation with the progression of keloids. The decrease of CAV1 contributed to the hyperactivation of fibrogenesis-associated RUNX2, a transcription factor germane to osteogenesis/chondrogenesis, and increased migratory ability in keloid fibroblasts.

  10. Dental abnormalities of four patients of a unique family associated with a 285kb duplication including the entire sequence of RUNX2.

  11. Presence of RUNX2 18 bps deletion variant in helathy individuals, its high population frequency, benign effect on the overall protein structure suggests that this variant is a population polymorphism rather than a cleidocranial dysplasia causative mutation.

  12. We performed histomorphometric analyses, and we quantified the expression levels of the osteogenic transcription factor RUNX2 in circulating mesenchymal stem cells in acromegalic patients. Our results showed an abnormal microarchitecture and demonstrated that bone impairment in these patients is associated with the upregulation of RUNX2 expression.

  13. Thus, PTH stimulated the expression of lnc-SUPT3H-1:16, miR-6797-5p and Runx2, and due to the sponging mechanism of lnc- SUPT3H-1:16 towards miR-6797-5p, Runx2 was protected, resulting in the promotion of osteoblast differentiation.

  14. RUNX2 gene transcription is regulated by the methylation status of specific CpG sites in the promoter and may determine RUNX2 availability in OA cartilage for transactivation of genes such as MMP13.

  15. Overexpression of Runx2 gene was beneficial for osteogenic differentiation of HUVECs, while overexpression of osterix gene did not show osteogenic differential potential.

  16. Mechanism of TRbeta repression of oncogenic gene expression: TRbeta recruitment of BRG1 induces chromatin compaction and diminishes RUNX2 expression. Therefore, BRG1-mediated chromatin remodeling may be obligatory for TRbeta transcriptional repression and tumor suppressor function in thyroid tumorigenesis.

  17. All these findings indicate that RUNX2 mutation can reduce the osteogenic capacity of dental follicle cells through inhibiting osteoblast-associated genes, thereby disturbing alveolar bone formation, which serves as a motive force for tooth eruption

  18. these data indicated that miR-23b was involved in TNF-alpha-mediated reduction of bone marrow mesenchymal stem cell osteogenesis by targeting runx2.

  19. that cross-talk between cAMP/PKA signaling and RUNX2 promotes a malignant phenotype of glioma cells

  20. Study identified RUNX2 to be targeted by miR-217 which directly bound to RUNX2 mRNA and inhibited its expression in bladder cancer cells. Also, findings demonstrated that RUNX2 expression was upregulated by hsa_circ_0000144. Moreover, rescue assays demonstrated that RUNX2 was a downstream effector molecule of hsa_circ_0000144/miR-217 network. These results revealed the oncogenic role of RUNX2 in bladder neoplasm.

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. quantitative data on the kinetics of gene expression is presented; new splice forms reported

  2. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. PHF20 increased the enrichment of H3K4me3 on the promoter of Runx2 followed by increased Runx2 promoter activity.

  2. Upon Runx2 silencing, autophagy-related proteins and RANKL were repressed in osteoblasts, thereby potentially causing the tooth eruption disorder.

  3. These results suggest a new mechanism whereby Smad4 controls chondrocyte hypertrophy by up-regulating Runx2 expression during skeletal development. The regulatory mechanism involving Smad4-mediated Runx2 activation uncovered here provides critical insights into bone development and pathogenesis of chondrodysplasia.

  4. our results indicate that Runx2 is weakly expressed in the LepR(+) population without osteoblastic commitment, and the LepR(+)Runx2-GFP(low) stromal cells sit atop the BM stromal hierarchy.

  5. Runx2+/- mice had defects in bone resorption, reduced circulating levels of bioactive osteocalcin, and reduced expression of osteocalcin's target genes in the brain. Consequently, they had significant impairment in cognitive function and increased anxiety-like behavior.

  6. Findings suggest that inhibition of Runx2 in chondrocytes could at least partially rescue destabilization of the medial meniscus (DMM) surgery-induced osteoarthritis (OA)-like defects.

  7. This study reveals that RUNX2 is differentially expressed in ATII cells vs. fibroblasts in lung fibrosis, which contributes to profibrotic cell function. Cell-specific targeting of RUNX2 pathways may represent a therapeutic approach for IPF.

  8. we have identified novel interaction between p38 MAPK and Runx2 enhances Runx2 transactivity, thus promoting vascular smooth muscle cells calcification

  9. By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells

  10. Results indicate that Dlx5 and Runx2 are critical factors for the upregulated Osterix expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.

  11. the expression of mouse Amtn gene in amelogenesis is mediated by Runx2/Cbfbeta complex. Runx2/Cbfbeta can bind to the two Runx2 binding motifs AACCACT (-1342/-1336) and AACCAAA (-98/-92) in the Amtn promoter and regulate Amtn gene expression.

  12. Mutant Runx2 regulates amelogenesis and osteogenesis through a miR-185-5p-Dlx2 axis.

  13. Puerarin may promote MC3T3E1 osteoblastlike cell viability and differentiation, which may be related to the downregulation of miR204 and the following activation of Runx2.

  14. mTOR/Raptor signaling is essential for bone formation in vivo through the regulation of Runx2 expression.

  15. these findings provide evidence that Cx43 and Runx2 functionally intersect in vivo to regulate cortical bone properties and affect osteoblast differentiation and proliferation

  16. miR-133a-5p targets the 3' UTR of RUNX2 mRNA to regulate the expression of RUNX2 negatively.

  17. muramyl dipeptide directly augmented osteoblast differentiation and bone-forming gene expression by Runx2 activation.

  18. Loss of Runx1 and Runx2 inhibits prostate cell motility.

  19. fetal administration of Entinostat/MS-275, a class I histone deacetylase (HDAC)-specific inhibitor, partially prevents delayed closure of cranial sutures in Runx2(+/-) mice strain of C57BL/6J by two mechanisms: 1) posttranslational acetylation of Runx2 protein, which stabilized the protein and activated its transcriptional activity; and 2) epigenetic regulation of Runx2 and other bone marker genes

  20. These data suggest that NaF promotes the osteoblastic differentiation of MC3T3-E1 cells through the Runx2/Osterix pathway and may be effective for the treatment of bone-related disorders.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

  2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

  3. The OPG expression levels decreased while those of RANKL and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. These data also indicate that MGP is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

  1. Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha-RUNX2 pathway.

RUNX2 Antigen Profile

Protein Summary

This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.

Gene names and symbols associated with RUNX2

  • runt related transcription factor 2 (RUNX2) antibody
  • runt-related transcription factor 2a (runx2a) antibody
  • runt related transcription factor 2 (Runx2) antibody
  • runt-related transcription factor 2 (Runx2) antibody
  • runt related transcription factor 2 (runx2) antibody
  • runt-related transcription factor 2 (LOC703331) antibody
  • runt-related transcription factor 2 (LOC100549663) antibody
  • runt related transcription factor 2 L homeolog (runx2.L) antibody
  • runt-related transcription factor 2 (RUNX2) antibody
  • aml3 antibody
  • Cbf antibody
  • CBF-alpha-1 antibody
  • Cbfa-1 antibody
  • cbfa1 antibody
  • ccd antibody
  • ccd1 antibody
  • CLCD antibody
  • LS3 antibody
  • OSF-2 antibody
  • osf2 antibody
  • pea2aa antibody
  • pebp2a1 antibody
  • pebp2a2 antibody
  • pebp2aa antibody
  • pebp2aa1 antibody
  • Pebpa2a antibody
  • RUNX2 antibody

Protein level used designations for RUNX2

PEA2-alpha A , PEBP2-alpha A , SL3-3 enhancer factor 1 alpha A subunit , SL3/AKV core-binding factor alpha A subunit , acute myeloid leukemia 3 protein , core-binding factor, runt domain, alpha subunit 1 , oncogene AML-3 , osteoblast-specific transcription factor 2 , polyomavirus enhancer-binding protein 2 alpha A subunit , runt-related transcription factor 2 , transcription factor Runx2a , AKV core binding factor , CBF-alpha-1 , PEBP2 alpha A , core binding factor alpha 1 , runt domain, alpha subunit 1 , core-binding factor subunit alpha-1 , runt related transcription factor 2 , transcription factor Cbfa1 , runt-related factor 2 , core binding factor alpha 1 subunit , runt-related transcription factor 2-like , Runx2 spliced isoform , runt-related transcription factor 2 type I , runt-related transcription factor 2 type II

GENE ID SPECIES
860 Homo sapiens
405784 Danio rerio
12393 Mus musculus
367218 Rattus norvegicus
373919 Gallus gallus
445986 Takifugu rubripes
472017 Pan troglodytes
703331 Macaca mulatta
100008943 Oryctolagus cuniculus
100033890 Equus caballus
100080409 Ornithorhynchus anatinus
100189546 Xenopus (Silurana) tropicalis
100222668 Taeniopygia guttata
100406564 Callithrix jacchus
100453201 Pongo abelii
100549663 Meleagris gallopavo
100555776 Anolis carolinensis
100619969 Monodelphis domestica
100037059 Xenopus laevis
536911 Bos taurus
100737965 Sus scrofa
474923 Canis lupus familiaris
100734175 Cavia porcellus
100861217 Capra hircus
101115489 Ovis aries
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