anti-Runt-Related Transcription Factor 2 (RUNX2) Antibodies

Human Runt-Related Transcription Factor 2 (RUNX2) interaction partners

1. Cocultivation attenuated the compressive forced induced increase of RUNX2 and P2RX7 gene expression in comparison to monoculture in both cell types

2. interaction between LEF1 and TAZ (WWTR1) is crucial for the osteoblastogenic activity of Wnt3a and that LEF1 and TAZ contribute to the cooperative effect of Wnt3a and BMP2 on osteoblast differentiation through association with Runx2.

3. the TGF-b/SMAD signaling pathway inhibits the ICMT-induced degeneration of endplate chondrocytes by regulating the miR-455-5p/RUNX2 axis

4. chromatin immunoprecipitation showed that higher methylation was associated with reduced SP7, RUNX2, and ERalpha binding to the SOST promoter in patients with osteoporosis; studies provide new insight into the role of SOST methylation in osteoporosis

5. Study found that high expression level of RUNX2 is related with a worst prognosis of colorectal cancer (CRC) and correlated with a worse prognosis and survival rate lower than five years.

6. circRUNX2 could sponge miR-203 and enhance RUNX2 expression, thus circRUNX2 prevents osteoporosis and may provide a novel therapeutic strategy for it.

7. a critical role for highly altered Ossification of the posterior longitudinal ligament (OPLL)-specific microRNA-10a in regulating the development of OPLL by modulating the ID3/RUNX2 axis.

8. The results suggest that RUNX2 may control paracrine signaling through regulation of ectodomain shedding at the cell surface of osteoblasts by directly suppressing Adam17 expression.

9. RUNX2 genetic variants were detected in seven unrelated children with cleidocranial dysplasia. The Gly223Val mutation made RUNX2 protein unable to quantitatively accumulate in the nucleus.

10. Results indicated a higher expression of miR-342-5p in coronary artery disease (CAD) patients compared to controls.

11. The results represent a conserved mechanism, by which CtBP2 serves as a NADH-dependent repressor of the p300-Runx2 transcriptional complex and thus affects bone formation.

12. Expression of lncRNA MALAT1 promoted Runt-related gene 2 (Runx2)-mediated osteogenic differentiation of adipose-derived mesenchymal stem cells by targeting miR-30.

13. mediates ST2 and Runx3 induction to cooperatively regulate hypertrophic differentiation of chondrocytes

14. High RUNX2 expression is associated with crohn's disease.

15. our results indicate that miR-302b functions as a tumour repressor in the invasion and migration of osteosarcoma by directly downregulating Runx2 expression and may be a potential therapeutic target for osteosarcoma.

16. Results show that TUC338 upregulates RUNX2 expression through miR-466 in prostate carcinoma tissues and cell lines.

17. restoring the function of Runx2-targeting by miR-342 and miR-363 in multiple myeloma cells may afford a therapeutic benefit by preventing multiple myeloma progression.Implications: miR-342 and miR-363-mediated downregulation of Runx2 expression in multiple myeloma cells prevents multiple myeloma progression

18. RUNX2 increased expression is associated with metastasis and epithelial mesenchymal transition in non-small cell lung cancer lung cancer.

19. DGCR5 negatively regulates miR-30d-5p, and it up-regulates Runx2 through miR-30d-5p, thereby inducing osteogenic differentiation of hMSCs, which may help to delay Postmenopausal osteoporosis development.

20. MiR-223 and miR-19a were found to regulate the expression of TWIST and Runx2, influence the RANKL-RANK pathway and the expression of MCP-1, and finally regulate the pathophysiological process of osteolytic bone destruction.

Zebrafish Runt-Related Transcription Factor 2 (RUNX2) interaction partners

1. quantitative data on the kinetics of gene expression is presented; new splice forms reported

2. Runx2 may have an evolutionarily conserved role in axis formation

Mouse (Murine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

1. there are different levels of dependency on Runx2 expression for successful ossification between neural crest-derived cells that have migrated to different locations.

2. Study in Runx2-/- mice revealed that number of osteoblast progenitors and their proliferation were dependent on the gene dosage of Runx2 in background. The expression of Fgfr2 and Fgfr3 was severely reduced in Runx2-/- calvariae. These results indicate that Runx2 is required for the proliferation of osteoblast progenitors and induces proliferation, at least partly, by regulating Fgfr2 and Fgfr3 expression.

3. Runx2 played critical roles in controlling enamel maturation by increasing synthesis of KLK4 and decreasing synthesis of AMELX, AMBN and ENAM

4. It identified NFIA and ATF3 as drivers of astrocyte differentiation from neural precursor cells while RUNX2 promotes astrocyte maturation.

5. MiR-23a transcriptional activated by Runx2 increases metastatic potential of mouse hepatoma cell via directly targeting Mgat3

6. The specific binding of ANCR with EZH2 suppressed RUNX2, thereby inhibiting osteogenesis.

7. IKKbeta negatively regulates vascular smooth muscle cell calcification through beta-catenin-Runx2 signaling.

8. Pax2 is essential for proliferation and osteogenic differentiation of mouse mesenchymal stem cells via Runx2.

9. DDR1 promotes RUNX2 activity and atherosclerotic vascular calcification in diabetes mellitus via phosphoinositide 3-kinase/Akt signaling.

10. Studied role of Kruppel-like factor 2 (KLF2) and runt related transcription factor 2 (Runx2) in promoting osteoblast differentiation.

11. PHF20 increased the enrichment of H3K4me3 on the promoter of Runx2 followed by increased Runx2 promoter activity.

12. Upon Runx2 silencing, autophagy-related proteins and RANKL were repressed in osteoblasts, thereby potentially causing the tooth eruption disorder.

13. These results suggest a new mechanism whereby Smad4 controls chondrocyte hypertrophy by up-regulating Runx2 expression during skeletal development. The regulatory mechanism involving Smad4-mediated Runx2 activation uncovered here provides critical insights into bone development and pathogenesis of chondrodysplasia.

14. our results indicate that Runx2 is weakly expressed in the LepR(+) population without osteoblastic commitment, and the LepR(+)Runx2-GFP(low) stromal cells sit atop the BM stromal hierarchy.

15. Runx2+/- mice had defects in bone resorption, reduced circulating levels of bioactive osteocalcin, and reduced expression of osteocalcin's target genes in the brain. Consequently, they had significant impairment in cognitive function and increased anxiety-like behavior.

16. Findings suggest that inhibition of Runx2 in chondrocytes could at least partially rescue destabilization of the medial meniscus (DMM) surgery-induced osteoarthritis (OA)-like defects.

17. This study reveals that RUNX2 is differentially expressed in ATII cells vs. fibroblasts in lung fibrosis, which contributes to profibrotic cell function. Cell-specific targeting of RUNX2 pathways may represent a therapeutic approach for IPF.

18. we have identified novel interaction between p38 MAPK and Runx2 enhances Runx2 transactivity, thus promoting vascular smooth muscle cells calcification

19. By using microRNA array, we identified a large number of microRNAs that showed different expression between wild-type Runx2 group and mutant groups. The aim of this study is to find out the effect of mmu-miR-1963, which was downregulated in all mutant Runx2 groups, on the ameloblast differentiation of LS8 cells

20. Results indicate that Dlx5 and Runx2 are critical factors for the upregulated Osterix expression in shPP2A cells, which is considered to be important for the accelerated osteoblast differentiation in these cells.

Rabbit Runt-Related Transcription Factor 2 (RUNX2) interaction partners

1. The results suggest that gene therapy using Runx2-modi fi ed dental pulp stem cells was more effective during bone deposition and new bone formation in tibia Distraction osteogenesis.

2. Runx2-modified adipose-derived stem cells promote tendon graft integration in anterior cruciate ligament reconstruction.

3. The OPG expression levels decreased while those of RANKL and RUNX2 increased during orthodontic tooth movement, which suggested that they play a role in the osteogenesis process and the reconstruction of periodontal tissue.

Xenopus laevis Runt-Related Transcription Factor 2 (RUNX2) interaction partners

1. These data also indicate that MGP is under dual regulation by runx2 through the use of various isoforms and context-dependent formation of transcriptional complexes.

Pig (Porcine) Runt-Related Transcription Factor 2 (RUNX2) interaction partners

1. Klotho gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha-RUNX2 pathway.