RUNX2 antibody

Catalog No. ABIN7270117

This Rabbit Monoclonal antibody specifically detects RUNX2 in WB and IP. It exhibits reactivity toward Human.

Quick Overview for RUNX2 antibody (ABIN7270117)

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This RUNX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-RUNX2 Antibody

Purpose: RUNX2 Rabbit mAb

Cross-Reactivity: Human, Mouse

Characteristics: Monoclonal Antibodies

Purification: Affinity purification

Immunogen: A synthesized peptide derived from human RUNX2

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IP,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,0.05 % BSA,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Alternative Name: RUNX2

Background: This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Two regions of potential trinucleotide repeat expansions are present in the N-terminal region of the encoded protein, and these and other mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing. [provided by RefSeq, Jul 2016],AML3, CBF-alpha-1, CBFA1, CCD, CCD1, CLCD, OSF-2, OSF2, PEA2aA, PEBP2aA,Cell Biology & Developmental Biology,Epigenetics & Nuclear Signaling,Extracellular Matrix,Extracellular Matrix_Bone,Hippo Signaling Pathway,Mesenchymal Stem Cells,Stem Cells,TGF-b-Smad Signaling Pathway_Target gene,Transcription Factors,RUNX2

Molecular Weight: kDa

Gene ID: 860

UniProt: Q13950