RUNX2 antibody (AA 251-351)

Catalog No. ABIN614560

This Mouse Monoclonal antibody specifically detects RUNX2 in WB, IF, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for RUNX2 antibody (AA 251-351) (ABIN614560)

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RUNX2 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Clone: 1D2

Product Details anti-RUNX2 Antibody

Binding Specificity: AA 251-351

Specificity: Recognizes Runt-related Transcription Factor 2 (RUNX2).

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogen: Partial Recombinant RUNX2 (NP_004339, 251 a.a. ~ 351 a.a) protein with GST tag.

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody (in aliquots) at -20 °C.

Target Details for RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Alternative Name: RUNX2

Background: RUNX family members are DNA-binding proteins that regulate the expression of genes involved in cellular differentiation and cell cycle progression. RUNX2 is essential for skeletal mineralization in that it stimulates osteoblast differentiation of mesenchymal stem cells, promotes chondrocyte hypertrophy and contributes to endothelial cell migration and vascular invasion of developing bones. Regulating RUNX2 expression may be a useful therapeutic tool for promoting bone formation. Mutations in the C-terminus of RUNX2 are associated with cleidocranial dysplasia syndrome, an autosomal-dominant skeletal dysplasia syndrome that is characterized by widely patent calvarial sutures, clavicular hypoplasia, supernumerary teeth, and short stature.Synonyms: AML-3, AML3, Acute myeloid leukemia 3 protein, CBFA1, Core-binding factor subunit alpha-1, OSF-2, OSF2, Osteoblast-specific transcription factor 2, PEA2-alpha A, PEBP2-alpha A, PEBP2A, Polyomavirus enhancer-binding protein 2 alpha A subunit, Runt-related transcription factor 2, SL3-3 enhancer factor 1 alpha A subunit, SL3/AKV core-binding factor alpha A subunit

Gene ID: 860

NCBI Accession: NP_001015051

UniProt: Q13950