RUNX2 antibody (AA 445-474)

Catalog No. ABIN392133

The Rabbit Polyclonal anti-RUNX2 antibody (Clone RB15321) (ABIN392133) specifically detects RUNX2 in WB, FACS and IHC (p). The antibody is reactive with Human samples.

Quick Overview for RUNX2 antibody (AA 445-474) (ABIN392133)

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RUNX2 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Clone: RB15321

Product Details anti-RUNX2 Antibody

Binding Specificity: AA 445-474

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RUNX2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 445-474 amino acids surrounding S465 of human RUNX2.

Isotype: Ig Fraction

Application Details

Application Notes: WB: 1:2000. IHC-P: 1:10~50. FC: 1:10~50

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Expiry Date: 6 months

Target Details for RUNX2

Target: RUNX2 (Runt-Related Transcription Factor 2 (RUNX2))

Alternative Name: RUNX2

Background: Runx2 is a member of the RUNX family of transcription factors. It is a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. It can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in the Runx2 gene have been associated with the bone development disorder cleidocranial dysplasia (CCD).

Molecular Weight: 56648

Gene ID: 860

NCBI Accession: NP_001015051, NP_001019801

UniProt: Q13950