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Filament-forming cytoskeletal GTPase.
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Human Polyclonal SEPT2 Primary Antibody for ICC, IF - ABIN4352727
Volceanov, Herbst, Biniossek, Schilling, Haller, Nölke, Subbarayal, Rudel, Zieger, Häcker: Septins arrange F-actin-containing fibers on the Chlamydia trachomatis inclusion and are required for normal release of the inclusion by extrusion. in mBio 2014
Show all 2 Pubmed References
Human Polyclonal SEPT2 Primary Antibody for ELISA, WB - ABIN451620
Kremer, Adang, Macara: Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7. in Cell 2007
Study discloses both SEPT2 and SEPT7 (show SEPT7 Antibodies) are essential for breast cancer cell migration and invasion by controlling MEK (show MAP2K1 Antibodies)/ERK (show EPHB2 Antibodies) MAPKs activation.
Depletion of septin 2 reduces Drp1 (show CRMP1 Antibodies) recruitment to mitochondria and results in hyperfused mitochondria and delayed FCCP-induced fission.
septins protect ErbB2 (show ERBB2 Antibodies) from ubiquitylation, endocytosis and lysosomal degradation. Septin (show SEPT6 Antibodies) oligomerization regulates persistent expression of ErbB2/HER2 (show ERBB2 Antibodies) in gastric cancer cells.
The results showed that SEPT2 has an oncogenic function through accelerated cell proliferation and invasion in biliary tract cancers, and is negatively regulated by miR (show MLXIP Antibodies)-140-5p.
From the nucleotide-free structure some interesting conclusions about the nucleotide binding properties of Cdc11 can be drawn; especially when aligning the structure with the structure of GDP bound Sept2
These results suggest that SEPTIN2-mediated cytoskeletal rearrangement and STATHMIN (show STMN1 Antibodies)-mediated differentiation may contribute to changes in cell morphology and differentiation of H/RS cells with CD99 (show CD99 Antibodies) upregulation in Hodgkin lymphoma.
Data indicate that forchlorfenuron (FCF) exhibits differential binding preference for septins SEPT2 and SEPT3 (show SEPT3 Antibodies).
Authors report here that the septins SEPT2, -9, -11, and probably -7 form fibrillar structures around the chlamydial inclusion.
Suggest PPAR-gamma (show PPARG Antibodies) activation down-regulates hepatocellular carcinoma cell SEPT2 levels to prevent tumor growth.
SEPT2 forms a 1:1:1 complex with SEPT7 (show SEPT7 Antibodies) and SEPT9 (show SEPT9 Antibodies).
Results indicate a stimulatory role of septin-2 and the dynamic reorganization of septin (show SEPT6 Antibodies) oligomers in exocytosis.
findings show SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium
Further analysis based on antibody staining of central and peripheral nerves revealed beta-adducin (show ADD2 Antibodies), septin 2, and sh3p8 (show SH3GL1 Antibodies) as putative paranodal proteins.
Significant level of SEPT2 expression was found in heart in a developmentally regulated fashion.
p85 (show ECM1 Antibodies) is thus involved in the spatial control of cytosolic division through regulation of Cdc42 (show CDC42 Antibodies) and septin 2, in a PI3K-activity independent manner.
study identified control of septin (show SEPT6 Antibodies) localization by the planar cell polarity (PCP (show PRCP Antibodies)) protein Fritz (show WDPCP Antibodies) as a crucial control point for both collective cell movement and ciliogenesis in embryos
Filament-forming cytoskeletal GTPase. Required for normal organization of the actin cytoskeleton. Plays a role in the biogenesis of polarized columnar-shaped epithelium by maintaining polyglutamylated microtubules, thus facilitating efficient vesicle transport, and by impeding MAP4 binding to tubulin. Required for the progression through mitosis. Forms a scaffold at the midplane of the mitotic splindle required to maintain CENPE localization at kinetochores and consequently chromosome congression. During anaphase, may be required for chromosome segregation and spindle elongation. Plays a role in ciliogenesis and collective cell movements. In cilia, required for the integrity of the diffusion barrier at the base of the primary cilium that prevents diffusion of transmembrane proteins between the cilia and plasma membranes (By similarity).
, neural precursor cell expressed developmentally down-regulated protein 5
, neural precursor cell expressed, developmentally down-regulated 5
, neural precursor cell expressed, developmentally down-regulated gene 5
, vascular endothelial cell specific protein 11
, septin A
, septin 2