Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 Proteins (SLC4A4)

SLC4A4 encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Additionally we are shipping SLC4A4 Antibodies (51) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
SLC4A4 8671 Q9Y6R1
SLC4A4 54403 O88343
Rat SLC4A4 SLC4A4 84484 Q9JI66
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Top SLC4A4 Proteins at antibodies-online.com

Showing 7 out of 10 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 70 to 75 Days
$16,301.58
Details
Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 30 to 35 Days
$5,465.26
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 70 to 75 Days
$11,428.37
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$414.29
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 9 to 11 Days
$364.64
Details
Human Un-conjugated   1 mg Log in to see 6 Days
$4,125.00
Details

SLC4A4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine) ,
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More Proteins for Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) Interaction Partners

Human Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) interaction partners

  1. A novel mechanism for variable phenotypic expressivity in band-shaped corneal dystrophy mediated by an AU-rich element (ARE)-creating mutation in SLC4A4 in three unrelated consanguineous families has been described.

  2. the structure of the membrane domain dimer of human NBCe1 at 3.9 A resolution by cryo electron microscopy, was determined.

  3. Common variants in the SLC4A4 gene might contribute to the variation of blood pressure responses to dietary sodium intake in Han Chinese population.

  4. miR (show MLXIP Proteins)-224 was significantly downregulated as ameloblasts differentiated, in parallel with upregulation of SLC4A4 and CFTR (show CFTR Proteins).

  5. The R298S is a temperature-sensitive mutation in NBCe1-A that results in instability of the colloidal system leading to abnormal aggregation.

  6. our results indicate that SLC4A4 contributes to the HCO3(-) transport and tumor cell phenotype

  7. These results revealed that insulin (show INS Proteins) can stimulate PT sodium transport even in type 2 diabetes with overt nephropathy.

  8. Data indicate that a domain-like structure formed by extracellular loop 3 (EL-3) is present at the SLC4 Na+-coupled transporter NBCe1-A dimeric interface.

  9. The cell membrane gene SLC4A4 and the trafficking regulator gene COPA (show COPA Proteins), which also plays an important role in early endosome maturation, were identified for the cellular entry of poly-arginine peptide.

  10. Our results demonstrate a surprisingly high apparent bicarbonate sensitivity mediated by NBCe1 in cortical astrocytes

Mouse (Murine) Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) interaction partners

  1. The data of this study showed for the first time that NBCe1 is a direct target of TGF-beta (show TGFB1 Proteins)/Smad4 (show SMAD4 Proteins) signaling.

  2. NBCe1 is necessary for normal proximal tubule NaDC-1 (show SLC13A2 Proteins) expression and 2-oxoglutarate metabolism, and deletion results in stimulation of a novel citrate reabsorptive pathway

  3. Reversed electrogenic sodium bicarbonate cotransporter 1 is the major acid loader during recovery from cytosolic alkalosis in mouse cortical astrocytes

  4. Study presented evidence for mouse cortical astrocytes and Xenopus oocytes that total "effective" cytosolic H+ buffering does not only include instantaneous, physicochemical buffering, but also rapid bicarbonate transport via NBCe1

  5. NBCe1 deletion caused a gene dose-related decrease in ammonia excretion

  6. Results demonstrate that transcriptional regulation and targeting of NBCe1, as well as functional operation of NBCe1, may occur through multiple signaling pathways

  7. The expression of NBCe1 in ameloblasts and the papillary layer cell depends on the developmental stage and possibly responds to pH changes.

  8. NBCe1 function is regulated by protein kinase C in murine colonic crypts.

  9. Our results demonstrate a surprisingly high apparent bicarbonate sensitivity mediated by NBCe1 in cortical astrocytes

  10. acidosis-induced NBCe1-A, but not NBCe1-B/C, trafficking is mediated by Rab8a (show RAB8A Proteins).

Cow (Bovine) Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) interaction partners

  1. AHCYL2 (show AHCYL2 Proteins) is a potential regulator of NBCe1-B in mammalian cells.

  2. these results suggest that IRBIT (show AHCYL1 Proteins) may reduce the apparent affinity for Mg(2 (show MCOLN1 Proteins)+)(i) in inhibition of NBCe1-B activity in mammalian cells.

  3. Data indicate that NBC1 (1Na(+)-3HCO(3)(-) cotransporter) plays a key role in transendothelial bicarbonate ion flux and is functional only at the basolateral membrane.

  4. These results suggest that Mg2 (show MCOLN1 Proteins)+ may be a cytosolic factor that limits intrinsic cotransport activity of NBCe1-B in mammalian cells.

Rabbit Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) interaction partners

  1. features of NBCe1-like activity in renal preparations are influenced by yet-to-be-identified renal factors

Zebrafish Solute Carrier Family 4, Sodium Bicarbonate Cotransporter, Member 4 (SLC4A4) interaction partners

  1. zAE1b, but not zNBCe1b, is involved in the basolateral transport pathways in Na(+) uptake/acid secretion mechanisms in zebrafish H(+)-ATPase (show ATP6AP1 Proteins) rich cells.

  2. NBCe1 in zebrafish shares many characteristics with mammalian NBCe1, including tissue distribution, importance in systemic water and electrolyte balance, and electrogenic transport of Na+ and HCO3-.

SLC4A4 Protein Profile

Protein Summary

This gene encodes a sodium bicarbonate cotransporter (NBC) involved in the regulation of bicarbonate secretion and absorption and intracellular pH. Mutations in this gene are associated with proximal renal tubular acidosis. Multiple transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with SLC4A4

  • solute carrier family 4 member 4 (SLC4A4)
  • solute carrier family 4 (anion exchanger), member 4 (Slc4a4)
  • solute carrier family 4 member 4 (Slc4a4)
  • solute carrier family 4 (sodium bicarbonate cotransporter), member 4a (slc4a4a)
  • AI835705 protein
  • HHNMC protein
  • HNBC1 protein
  • id:ibd2520 protein
  • KNBC protein
  • NBC protein
  • Nbc1 protein
  • NBC2 protein
  • Nbc4 protein
  • nbce1 protein
  • NBCe1-A protein
  • PNBC protein
  • si:dkey-256m11.1 protein
  • slc4a4 protein
  • SLC4A5 protein

Protein level used designations for SLC4A4

Na(+)/HCO3(-) cotransporter , electrogenic sodium bicarbonate cotransporter 1 , kNBC1 , sodium bicarbonate cotransporter 1 (sodium bicarbonate cotransporter, kidney; sodium bicarbonate cotransporter, pancreas) , solute carrier family 4, sodium bicarbonate cotransporter, member 4, brain type , solute carrier family 4, sodium bicarbonate cotransporter, member 5 , sodium bicarbonate cotransporter member 4 , solute carrier family 4 member 4 , solute carrier family 4, sodium bicarbonate cotransporter member 4 , electrogenic sodium bicarbonate cotransporter NBCe1 variant D , pancreas sodium bicarbonate cotransporter , sodium bicarbonate cotransporter , solute carrier family 4, sodium bicarbonate cotransporter, member 4 , NBC-like protein , Na+HCO3- cotransporter 4 , solute carrier family 4 (anion exchanger), member 4 , solute carrier family 4, member 4 , duodenal sodium bicarbonate cotransport protein NBC1 , Na+-HCO3- exchanger , NBC1 , electrogenic Na+ bicarbonate cotransporter , solute carrier family 4, member 4a

GENE ID SPECIES
8671 Homo sapiens
503546 Sus scrofa
54403 Mus musculus
84484 Rattus norvegicus
282360 Bos taurus
100008727 Oryctolagus cuniculus
475171 Canis lupus familiaris
568631 Danio rerio
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