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Putative taste receptor. Additionally we are shipping Taste Receptor, Type 1, Member 2 Kits (7) and Taste Receptor, Type 1, Member 2 Proteins (6) and many more products for this protein.
Showing 10 out of 76 products:
Human Polyclonal TAS1R2 Primary Antibody for ELISA, WB - ABIN408697
Jang, Kokrashvili, Theodorakis, Carlson, Kim, Zhou, Kim, Xu, Chan, Juhaszova, Bernier, Mosinger, Margolskee, Egan: Gut-expressed gustducin and taste receptors regulate secretion of glucagon-like peptide-1. in Proceedings of the National Academy of Sciences of the United States of America 2007
genetic association studies in population of preschool-aged children in Guelph, Ontario: Data suggest that SNPs in CD36 (show CD36 Antibodies) (rs1761667), TAS1R2 (rs35874116), and TAS2R38 (show TAS2R38 Antibodies) (rs713598) are associated with snacking behavior in the population studied. [PILOT PROJECTS]
We observe that binding of agonists to VFD2 of TAS1R2 leads to major conformational changes to form a TM6/TM6 interface between TMDs of TAS1R2 and TAS1R3 (show TAS1R3 Antibodies), which is consistent with the activation process observed biophysically on the metabotropic glutamate receptor 2 (show GRM2 Antibodies) homodimer.
Alleles from each TAS1R2 locus (GG compared with AA alleles of rs12033832, and CT/CC compared with TT alleles of rs35874116) were related to higher consumption of carbohydrates (% energy) and higher amount of sweet foods, respectively (P<0.05).
The molecular anatomy of sweet taste receptor dimers T1R2-T1R3 (show TAS1R3 Antibodies) has been presented.
no significant associations between GLUT2 (show SLC2A2 Antibodies) and/or TAS1R2 polymorphisms and fillings were found, but allele frequencies of the TAS1R2 variant were marginally significantly different between children with DMFT = 0 and DMFT >/=1. no significant interaction between both genes and risk of dental caries was found. GLUT2 (show SLC2A2 Antibodies) and TASR1 (show SRSF10 Antibodies) polymorphisms may influence the risk of caries in the Czech population
In conclusion, the Val/Val genotype of TAS1R2 was associated with a higher carbohydrate intake and HTG.
high-risk caries experience (>8 caries) was found to be associated with TAS1R2 rs35874116 homozygous polymorphic genotype.
The rs12033832 single nucleotide polymorphism in TAS1R2 is associated with sucrose taste and sugar intake, but the effect differs depending on BMI
human and mouse membrane trafficking systems for sweet taste receptors T1r2 and T1r3 (show TAS1R3 Antibodies)
effects of artificial sweeteners on adipose tissue may be largely independent of the classical sweet taste receptors, T1R2 and T1R3 (show TAS1R3 Antibodies)
Data, including data from studies with mutant and knockout mice, suggest that Tas1R3 (show TAS1R3 Antibodies) and Tas1R2 are expressed endogenously in osteoclast stem cells; their expression levels parallel robust increase in osteoclast biomarker Ctsk (show CTSK Antibodies) during osteoclast differentiation. (Ctsk (show CTSK Antibodies) = cathepsin K (show CTSK Antibodies))
mice lacking T1R2 + T1R3 (show TAS1R3 Antibodies) and controls were tested in a taste discrimination task to determine whether maltodextrins are 1 (show VPS52 Antibodies)) detectable when both receptor subunits are absent and 2) perceptually distinct from that of sucrose. Some KO mice were only sensitive to the higher Polycose concentrations, implicating potential allelic variation in the putative polysaccharide receptor pathways unmasked by the absence of T1R2+T1R3 (show TAS1R3 Antibodies).
results implicate each subunit of the T1R2+T1R3 (show TAS1R3 Antibodies) dimer in the behavioral response to P-containing taste compounds
T1R2 plays an important role in glucose homeostasis during diet-induced obesity through the regulation of yet to be identified molecular mechanisms that alter energy disposal and utilization in peripheral tissues. T1r2 was upregulated in the adipose tissue of wild type mice in response to high fat/low carbohydrate diet, and their expression positively correlated with fat mass and glucose intolerance.
Mice possess two taste transduction pathways for sugars. One mediates behavioral attraction to sugars and requires an intact T1r2+T1r3 (show TAS1R3 Antibodies). The other mediates cephalic phase insulin (show INS Antibodies) release but does not require an intact T1r2+T1r3 (show TAS1R3 Antibodies).
T1R2 and T1R3 (show TAS1R3 Antibodies) knockout mice have increased cortical bone mass and trabecular remodeling.
T1R2+3 heterodimer is the principal receptor that mediates taste detection of natural sweeteners, but not of all carbohydrate stimuli.
Genetic ablation of the sweet TR protein T1R2 obliterates fructose-induced insulin (show INS Antibodies) release and its potentiating effects on glucose-stimulated insulin (show INS Antibodies) secretion in vitro and in vivo.
Putative taste receptor. TAS1R2/TAS1R3 recognizes diverse natural and synthetic sweeteners (By similarity).
taste receptor type 1 member 2
, G protein-coupled receptor 71
, G-protein coupled receptor 71
, sweet taste receptor T1R2
, aldehyde dehydrogenase 4 family, member A1
, taste receptor TR2
, candidate taste receptor T1R2