Thymocyte Selection Associated (THEMIS) ELISA Kits

THEMIS encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. Additionally we are shipping THEMIS Antibodies (82) and THEMIS Proteins (4) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
THEMIS 387357 Q8N1K5
THEMIS 210757 Q8BGW0
THEMIS 540554 A5D789
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Top THEMIS ELISA Kits at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Reactivity Sensitivity Range Images Quantity Supplier Delivery Price Details
Human < 0.188 ng/mL 0.313 ng/mL - 20 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Mouse < 0.094 ng/mL 0.156 ng/mL - 10 ng/mL   96 Tests Log in to see 11 to 18 Days
$810.17
Details
Cow
  96 Tests Log in to see 15 to 18 Days
$1,029.60
Details

More ELISA Kits for THEMIS Interaction Partners

Human Thymocyte Selection Associated (THEMIS) interaction partners

  1. we have demonstrated mutually exclusive use of exon 1 and 2 amongst 16 novel THEMIS isoforms. We also show inverse correlation between THEMIS expression in human CD4+ T-cells and dosage of the multiple sclerosis risk allele at rs13204742, driven by reduced expression of exon 1- containing isoforms

  2. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  3. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  4. THEMIS showed higher mRNA expression in active celiac disease compared with treated patients and controls.

  5. THEMIS binding to GRB2 was required for thymocyte development.

  6. Themis1 exhibits the same potential to restore T cell development and T cell receptor-mediated signaling in Themis1-deficient mice.

  7. SPOP mutations may define a new molecular subtype of prostate cancer.

  8. specific role for THEMIS in early TCR signalosome function

  9. Functional characterization of the homologous mouse gene.

  10. Functional analysis of the mouse gene by knockout, and comparison of the mouse and human proteins.

Mouse (Murine) Thymocyte Selection Associated (THEMIS) interaction partners

  1. This positive regulation of Shp1 activity by Themis is found in thymocytes, but not in peripheral T cells.

  2. this study demonstrates the potential role of Themis1 in the suppressive functions of regulatory T cells.

  3. Themis1 acts as a positive regulator of TCR signaling during thymocyte development by promoting Vav1 activity and Grb2 stability

  4. the positive selection of immature CD4+CD8+ double-positive thymocytes and their commitment to the CD4+CD8- single-positive stage are impaired in Themis-/- mice

  5. we found that THEMIS directly regulated the catalytic activity of the tyrosine phosphatase SHP-1.

  6. The results demonstrate an essential requirement for the PRR and NLS motifs but not the conserved CABIT cysteines for Themis1 function.

  7. THEMIS is required for the development and ultimately the function of proinflammatory T cells.

  8. the THEMIS:SHP complex dampens early TCR signalling by a previously unknown molecular mechanism that favours T-cell survival.

  9. by dampening mild T-cell receptor signals Themis increases the affinity threshold for activation, enabling positive selection of T cells with a naive phenotype in response to low-affinity self-antigens

  10. specific role for THEMIS in early TCR signalosome function

  11. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection

  12. Themis functions to sustain and/or integrate signals required for proper lineage commitment and maturation.

  13. Themis had high expression in thymocytes between the pre-T cell antigen receptor and positive-selection checkpoints and low expression in mature T cells. Themis-deficient T-cells showed defective positive selection, resulting in fewer mature thymocytes.

  14. Gasp associates with Grb2 and is required for positive selection of thymocytes

THEMIS Antigen Profile

Antigen Summary

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with THEMIS

  • thymocyte selection associated (THEMIS) antibody
  • thymocyte selection associated (Themis) antibody
  • thymocyte selection associated (themis) antibody
  • A430108D01 antibody
  • bA325O24.3 antibody
  • bA325O24.4 antibody
  • BB160712 antibody
  • C6orf190 antibody
  • C6orf207 antibody
  • C9H6ORF190 antibody
  • E430004N04Rik antibody
  • Gasp antibody
  • im:7138580 antibody
  • SPOT antibody
  • thylex antibody
  • tsepa antibody

Protein level used designations for THEMIS

thymocyte selection associated , thymocyte selection pathway associated , GRB2-associated protein , protein THEMIS , signaling phosphoprotein specific for T cells , thymocyte expressed molecule involved in selection , thymocyte-expressed molecule involved in selection , grb2-associating protein , protein thylex , thymus lymphocyte exclusively expressed , Thymocyte-expressed molecule involved in selection

GENE ID SPECIES
462992 Pan troglodytes
100030867 Monodelphis domestica
100073059 Equus caballus
100078185 Ornithorhynchus anatinus
100403177 Callithrix jacchus
100454796 Pongo abelii
100482128 Ailuropoda melanoleuca
100546083 Meleagris gallopavo
100595098 Nomascus leucogenys
387357 Homo sapiens
210757 Mus musculus
540554 Bos taurus
555433 Danio rerio
484120 Canis lupus familiaris
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