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UPF3A encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. Additionally we are shipping UPF3A Antibodies (32) and and many more products for this protein.
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The complex between the interacting domains of human UPF2 and UPF3b at a 1.95 A resolution.
hUpf3a is much less active than hUpf3b to induce NMD and to stimulate translation
The Upf complex communicates with the exon-junction complex and triggers nonsense-mediated decay in the cytoplasm.
Results suggest that UPF3A levels are tightly regulated by a post-transcriptional switch to maintain appropriate levels of NMD substrates in cells containing different levels of UPF3B.
binds to spliced mRNAs upstream of exon-exon junctions; is part of mRNP complexes that are ready for nuclear export and that participate in nonsense-mediated mRNA decay
This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene.
UPF3 regulator of nonsense transcripts homolog A
, regulator of nonsense transcripts 3A
, UPF3 regulator of nonsense transcripts homolog A (yeast)
, regulator of nonsense transcripts 3A-like
, nonsense mRNA reducing factor 3A
, up-frameshift suppressor 3 homolog A