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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Additionally we are shipping UBE4B Proteins (3) and many more products for this protein.
Showing 10 out of 47 products:
Human Polyclonal UBE4B Primary Antibody for IHC, IHC (p) - ABIN4363967
Arabi, Ullah, Branca, Johansson, Bandarra, Haneklaus, Fu, Ariës, Nilsson, Den Boer, Pokrovskaja, Grandér, Xiao, Rocha, Lehtiö, Sangfelt: Proteomic screen reveals Fbw7 as a modulator of the NF-κB pathway. in Nature communications 2012
miR (show MLXIP Antibodies)-1301 functions as a tumor suppressor that inhibits tumor cell migration and invasion in multiple human cancer cells by regulating the UBE4B-p53 (show TP53 Antibodies) pathway.
UBE4B promotes endogenous phospho-p53 (show TP53 Antibodies)(S15 (show FBLN3 Antibodies)) and phospho-p53 (show TP53 Antibodies)(S392) degradation in response to gamma irradiation. UBE4B plays an important role in regulating phosphorylated p53 (show TP53 Antibodies) following DNA damage.
UBE4B overexpression promotes the oncogenic properties of HCC (show FAM126A Antibodies) and is correlated with an unfavorable prognosis in HCC (show FAM126A Antibodies) patients.
UBE4B regulates p53 (show TP53 Antibodies) in breast cancer
We propose a model in which the coordinated action of UBE4B, ESCRT-0, and the deubiquitinating enzyme USP8 (show USP8 Antibodies) enable the endosomal sorting and lysosomal degradation of the EGFR (show EGFR Antibodies).
UBE4B-mediated growth factor receptor (show RYK Antibodies) trafficking may contribute to the poor prognosis of patients who have neuroblastoma (show ARHGEF16 Antibodies) tumors with 1p36 deletions.
The regulated expression of these UFD2a isoforms most likely imparts divergent functions that are important for myogenesis.
we found somatic mutations of HERC2 (show HERC2 Antibodies), HERC3 (show HERC3 Antibodies), TRIP12 (show TRIP12 Antibodies), UBE2Q1 (show UBE2Q1 Antibodies) and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability
data indicate that amplification and overexpression of UBE4B represent previously undescribed molecular mechanisms of inactivation of p53 (show TP53 Antibodies) in brain tumors
determined structures of E4B U box free and bound to UbcH5c (show UBE2D3 Antibodies) and Ubc4 (show UBE2D2 Antibodies) E2s; findings show E4B U box is a monomer stabilized by a network of hydrogen bonds; findings suggest allosteric regulation of UbcH5c (show UBE2D3 Antibodies) and Ubc4 (show UBE2D2 Antibodies) by E4B U box
Characterization of the UFD2a gene.
UFD2a is essential for the development of cardiac muscle, as well as for the protection of spinocerebellar neurons from degeneration induced by endoplasmic reticulum stress.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes an additional conjugation factor, E4, which is involved in multiubiquitin chain assembly. This gene is also the strongest candidate in the neuroblastoma tumor suppressor genes. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
ubiquitin conjugation factor E4 B
, ubiquitination factor E4B (UFD2 homolog, yeast)
, ubiquitination factor E4B, UFD2 homolog
, ubiquitin fusion degradation protein 2
, UFD2A-III/UBE4B-III splice isoform
, homologous to yeast UFD2
, homozygously deleted in neuroblastoma 1
, homozygously deleted in neuroblastoma-1
, ubiquitin-fusion degradation protein 2
, ubiquitination factor E4B (homologous to yeast UFD2)