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Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity).. Additionally we are shipping UBE2O Antibodies (45) and many more products for this protein.
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UBE2O specifically targets AMPKalpha2 (show PRKAA2 Proteins) for ubiquitination and degradation, and thereby promotes activation of the mTOR (show FRAP1 Proteins)-HIF1alpha (show HIF1A Proteins) pathway.
UBE2O defines an atypical ubiquitin-signaling pathway that coordinates the function of BAP1 (show RNF2 Proteins).
UBE2O negatively regulates TRAF6 (show TRAF6 Proteins)-mediated NF-kappaB (show NFKB1 Proteins) activation by inhibiting TRAF6 (show TRAF6 Proteins) polyubiquitination.
monoubiquitinated SMAD6 (show SMAD6 Proteins) impairs the binding affinity of non-modified SMAD6 (show SMAD6 Proteins) to the BMP type I receptor. Moreover, UBE2O and SMAD6 (show SMAD6 Proteins) cooperated in the regulation of BMP7 (show BMP7 Proteins)-induced adipogenesis
these results elucidate an oncogenic role for UBE2O in promoting mTOR (show FRAP1 Proteins)-HIF1a (show HIF1A Proteins) signaling, and suggest that therapeutic targeting of UBE2O may restore AMPKa2 (show PRKAA2 Proteins) to suppress tumorigenesis.
Catalyzes the covalent attachment of ubiquitin to other proteins (By similarity).
ubiquitin-conjugating enzyme E2O
, ubiquitin-conjugating enzyme E2 O-like
, ubiquitin carrier protein O
, ubiquitin-conjugating enzyme E2 O
, ubiquitin-conjugating enzyme E2 of 230 kDa
, ubiquitin-conjugating enzyme E2-230K
, ubiquitin-protein ligase O
, ubiquitinating enzyme E2-230 kDa