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SARS2 encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. Additionally we are shipping SARS2 Proteins (5) and and many more products for this protein.
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These data further support that the mitochondrial tRNA(Ser(UCN)) gene is the hot spot for mutations associated with hearing loss.
Late-onset mitochondrial myopathy with dystrophic changes due to a G7497A mutation in the mitochondrial tRNA(Ser(UCN)) gene.
NF-Y type CCAAT boxes are found preferentially in bidirectional Mrps12/Sarsm promoters, but many such promoters lack them and must be regulated in another way.
This gene encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. This gene is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
serine--tRNA ligase, mitochondrial
, seryl-tRNA synthetase, mitochondrial
, seryl-tRNA(Ser/Sec) synthetase
, mitochondrial seryl-tRNA synthetase
, serine tRNA ligase 2, mitochondrial
, serine-tRNA ligase, mitochondrial
, seryl-aminoacyl-tRNA synthetase 2