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ACER1 Products

(Alkaline Ceramidase 1 (ACER1))

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Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]\; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010].

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Featured ACER1 Categories

ACER1 Antibodies

High quality antibodies with extensive validation data.

ACER1 Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended ACER1 Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (3)
Cat. No. ABIN6260068
Quantity 100 μL
Datasheet Datasheet
Reactivity Human
Application WB, ELISA
Validations
  • (1)
Cat. No. ABIN7185928
Quantity 100 μg
Datasheet Datasheet
Reactivity Human
Application WB
Validations
  • (1)
Cat. No. ABIN1536908
Quantity 400 μL
Datasheet Datasheet

Recommended ACER1 Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3104294
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
  • (1)
Cat. No. ABIN3126824
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
Cat. No. ABIN2714568
Quantity 20 μg
Datasheet Datasheet

Synonyms and alternative names related to ACER1

alkaline ceramidase 1 (ACER1), alkaline ceramidase 1 (acer1), alkaline ceramidase 1 (Acer1), 2310024P18Rik, AI662009, ALKCDase1, Alkcdase1, ASAH3, asah3, Asah3, Cer1, zgc:110285

Protein level used designations for ACER1

  • N-acylsphingosine amidohydrolase (alkaline ceramidase) 3
  • alkaline ceramidase 1
  • N-acylsphingosine amidohydrolase 3
  • acylsphingosine deacylase 3
  • alkCDase 1
  • alkaline CDase 1
  • alkaline cdase 1
  • maCER1
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