alpha-conotoxin IMI (alpha conotoxin IMI)

Catalog No. ABIN1540049

Product Details

Target: alpha-conotoxin IMI

Application: Blocking Reagent (BR)

Purpose: alpha-conotoxin IMI blocks nAChR

Sequence: Gly-Cys2-Cys3-Ser-Asp-Pro-Arg-Cys8-Ala-Trp-Arg-Cys12-NH2Disulfide bonds between Cys2-Cys8 and Cys3-Cys12

Application Details

Restrictions: For Research Use only

Handling

Target Details

Target: alpha-conotoxin IMI

Background: Alpha-conotoxin IMI has been isolated from the venom of the cone snail Conus mperialis. alpha-conotoxin IMI acts on postsynaptic membranes, and binds onto and inhibits nicotinic acetylcholine receptors (nAChR). This toxin blocks mammalian neuronal nAChRs (alpha3/ß2 > alpha7 > alpha3/ß4). It has no effect on nAChRs composed of alpha2/ß2, alpha3/ß2, alpha4/ß2, alpha2/ß4, alpha3/ß4, or alpha4/ß4 subunits. alpha-conotoxins IMI acts independently of voltage value. This toxin is highly active against the neuromuscular receptor in frog.

Molecular Weight: 1352.92 Da

CAS-No: 156467-85-5