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Adenylosuccinate Lyase Products

(Adenylosuccinate Lyase (ADSL))

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Adenylsuccinate lyase is involved in both de novo synthesis of purines and formation of adenosine monophosphate from inosine monophosphate. It catalyzes two reactions in AMP biosynthesis: the removal of a fumarate from succinylaminoimidazole carboxamide (SAICA) ribotide to give aminoimidazole carboxamide ribotide (AICA) and removal of fumarate from adenylosuccinate to give AMP. Adenylosuccinase deficiency results in succinylpurinemic autism, psychomotor retardation, and , in some cases, growth retardation associated with muscle wasting and epilepsy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Featured Adenylosuccinate Lyase Categories

Adenylosuccinate Lyase Antibodies

High quality antibodies with extensive validation data.

Adenylosuccinate Lyase ELISA Kits

Reliable ELISA kits for a wide range of species.

Adenylosuccinate Lyase Proteins

Proteins for various applications incl. WB, ELISA, IF etc.

Recommended Adenylosuccinate Lyase Antibodies

Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity Dog, Human, Monkey, Rat
Application FACS, IHC, WB
Validations
  • (3)
Cat. No. ABIN2715763
Quantity 0.1 mL
Datasheet Datasheet
Reactivity Human
Application ELISA, IHC, WB
Validations
  • (2)
Cat. No. ABIN7143352
Quantity 100 μL
Datasheet Datasheet
Reactivity Human, Mouse, Rat
Application IF, WB
Validations
  • (2)
Cat. No. ABIN7262084
Quantity 200 μL
Datasheet Datasheet

Recommended Adenylosuccinate Lyase ELISA Kits

Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
Cat. No. ABIN6964640
Quantity 96 tests
Datasheet Datasheet
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
Cat. No. ABIN6730398
Quantity 96 tests
Datasheet Datasheet
Reactivity Mouse
Analytical Method
Validations
Cat. No. ABIN1120655
Quantity 96 tests
Datasheet Datasheet

Recommended Adenylosuccinate Lyase Proteins

Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity Human
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3086712
Quantity 1 mg
Datasheet Datasheet
Reactivity Mouse
Source Insect Cells
Validations
  • (1)
Cat. No. ABIN3119817
Quantity 1 mg
Datasheet Datasheet
Reactivity Human
Source Wheat germ
Validations
  • (1)
Cat. No. ABIN1344500
Quantity 10 μg
Datasheet Datasheet

Latest Publications for our Adenylosuccinate Lyase products

van Straten, van Steenbeek, Grinwis, Favier, Kummeling, van Gils, Fieten, Groot Koerkamp, Holstege, Rothuizen, Spee: "Aberrant expression and distribution of enzymes of the urea cycle and other ammonia metabolizing pathways in dogs with congenital portosystemic shunts." in: PLoS ONE, Vol. 9, Issue 6, pp. e100077, (2014) (PubMed).

Sadasivan, Vasamsetti, Singh, Siddaraju, Khan, Oommen, Jagannath, Rao: "Modulation of de novo purine biosynthesis leads to activation of AMPK and results in improved glucose handling and insulin sensitivity." in: Journal of diabetes and metabolic disorders, Vol. 13, pp. 51, (2014) (PubMed).

Baresova, Skopova, Sikora, Patterson, Sovova, Zikanova, Kmoch: "Mutations of ATIC and ADSL affect purinosome assembly in cultured skin fibroblasts from patients with AICA-ribosiduria and ADSL deficiency." in: Human molecular genetics, Vol. 21, Issue 7, pp. 1534-43, (2012) (PubMed).

Stadler, Hjelmare, Neumann, Jonasson, Pepperkok, Uhlén, Lundberg: "Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy." in: Journal of proteomics, Vol. 75, Issue 7, pp. 2236-51, (2012) (PubMed).

Blumstein, Faundez, Nakatsu, Saito, Ohno, Kelly: "The neuronal form of adaptor protein-3 is required for synaptic vesicle formation from endosomes." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 21, Issue 20, pp. 8034-42, (2001) (PubMed).

Zhen, Jiang, Feng, Bright, Peden, Seymour, Novak, Elliott, Gorin, Robinson, Swank: "Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse." in: Blood, Vol. 94, Issue 1, pp. 146-55, (1999) (PubMed).

Ooi, Moreira, DellAngelica, Poy, Wassarman, Bonifacino: "Altered expression of a novel adaptin leads to defective pigment granule biogenesis in the Drosophila eye color mutant garnet." in: The EMBO journal, Vol. 16, Issue 15, pp. 4508-18, (1997) (PubMed).

Synonyms and alternative names related to Adenylosuccinate Lyase

adenylosuccinate lyase (ADSL), adenylosuccinate lyase (adsl), adenylosuccinate lyase L homeolog (adsl.L), adenylosuccinate lyase (ASL), adenylosuccinate lyase (purB), adenylosuccinase; ASL (purB), adenylosuccinate lyase (purB,adsL), adenylosuccinate lyase (Mrub_2293), adenylosuccinate lyase (MMAH_RS02975), adenylosuccinate lyase (Arnit_0089), adenylosuccinate lyase (Mesil_1058), adenylosuccinate lyase (Slip_0597), adenylosuccinate lyase (Trad_2452), adenylosuccinate lyase (Deba_0652), adenylosuccinate lyase (Toce_1174), Adenylosuccinate lyase (Acear_2324), Adenylosuccinate lyase (Igag_0272), adenylosuccinate lyase (Saut_2156), Adenylosuccinate lyase (Fbal_1996), adenylosuccinate lyase (Ndas_2434), adenylosuccinate lyase (Ilyop_0196), adenylosuccinate lyase (Lbys_2961), adenylosuccinate lyase (MFER_RS02920), adenylosuccinate lyase (Palpr_2192), adenylosuccinate lyase (Calni_0061), adenylosuccinate lyase (Ftrac_3746), L-Aspartase-like family protein (AT1G36280), Adenylosuccinate lyase (Olsu_1764), adenylosuccinate lyase (Adsl), Adl, adsL, AMPS, ASASE, ASL, Asl, F15C21.8, F15C21_8, fi60b04, MGC53383, MGC69239, purB, wu:fi60b04, zgc:56061

Protein level used designations for Adenylosuccinate Lyase

  • adenylosuccinate lyase
  • Adenylosuccinate lyase
  • adenylosuccinate lyase-like
  • adenylosuccinase
  • ASase
  • adenylosuccinate lyase 1
  • test
  • ASL
  • adenysuccinate lyase
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