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Lamin A/C antibody (R453W)

This Mouse Monoclonal antibody specifically detects Lamin A/C in WB, IF, IP and ICC. It exhibits reactivity toward Humanand has been mentioned in 1 publication.
Catalog No. ABIN1042618

Quick Overview for Lamin A/C antibody (R453W) (ABIN1042618)

Target

See all Lamin A/C (LMNA) Antibodies
Lamin A/C (LMNA)

Reactivity

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Human

Host

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Mouse

Clonality

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Monoclonal

Conjugate

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This Lamin A/C antibody is un-conjugated

Application

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Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunocytochemistry (ICC)

Clone

12A-2F5
  • Binding Specificity

    • 10
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    R453W

    Specificity

    EDMD-associated lamin A/C mutant R453W

    Purification

    Protein G

    Immunogen

    KLH-coupled peptide from Lamin A/C, human (Immunogen Sequence: 449-GKFVWLRNK-457).

    Isotype

    IgG1
  • Application Notes

    Optimal antibody dilution should be determined by titration, however as a guideline try,WB: 1:8,000 (Predicted Mw is 65 kDa)

    Comment

    Myeloma, fusion partners: X63-Ag8.653

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    Purified antibody (from supernatant) containing PBS + 0.1 % sodium azide

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Roblek, Schüchner, Huber, Ollram, Vlcek-Vesely, Foisner, Wehnert, Ogris: "Monoclonal antibodies specific for disease-associated point-mutants: lamin A/C R453W and R482W." in: PLoS ONE, Vol. 5, Issue 5, pp. e10604, (2010) (PubMed).

  • Target

    Lamin A/C (LMNA)

    Alternative Name

    Lamin A+C R453W

    Background

    Synonyms:
    LMNA

    Pathways

    Apoptosis, Caspase Cascade in Apoptosis, ER-Nucleus Signaling, Protein targeting to Nucleus
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