SDPR antibody (N-Term)

Catalog No. ABIN1077452

Product Details anti-SDPR Antibody

Target: SDPR (Serum Deprivation Response (SDPR))

Binding Specificity: N-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SDPR antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Specificity: It is predicted to not cross-react with other members of the cavin family.

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal SDPR antibody was raised against an 18 amino acid peptide near the amino terminus of human SDPR.

Isotype: IgG

Application Details

Application Notes: SDPR antibody can be used for detection of SDPR by Western blot at 1 - 2 μg/mL.

Comment:

(NT) Serum deprivation-response protein

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Target Details for SDPR

Target: SDPR (Serum Deprivation Response (SDPR))

Alternative Name: SDPR (SDPR Products)

Synonyms: CAVIN2 antibody, PS-p68 antibody, SDR antibody, cavin-2 antibody, sdr antibody, MGC84112 antibody, sdprb antibody, wu:fb39c08 antibody, wu:fk90b02 antibody, zgc:92231 antibody, caveolae associated protein 2 antibody, caveolae associated 2 antibody, caveolae associated protein 2 S homeolog antibody, serum deprivation response antibody, caveolae associated protein 2b antibody, CAVIN2 antibody, Cavin2 antibody, cavin2.S antibody, SDPR antibody, cavin2b antibody

Background: The serum deprivation-response protein (SDPR) is a calcium-independent phospholipid-binding protein whose expression is increased in serum-starved cells. SDPR is a substrate for protein kinase C (PKC) phosphorylation and recruits the polymerase I and transcript release factor (PTRF) to caveolae. Removal of this protein causes caveolae loss and its over-expression results in caveolae deformation and membrane tubulation. Both SDPR and PTRF, as well as the other member of the cavin family PRKCDBP were down regulated in breast cancer cell lines and breast tumor tissue, suggesting that expression of the cavin family proteins could be a useful prognostic indicator of breast cancer progression.
Synonyms: Serum deprivation response, SDR, serum deprivation-response protein, CAVIN2, PS-p68, cavin-2, phosphatidylserine binding protein

Molecular Weight: 47 kDa

Gene ID: 8436

NCBI Accession: NP_004648