beta Amyloid antibody (N-Term)

Catalog No. ABIN1105349

The Mouse Monoclonal anti-beta Amyloid antibody is suitable to detect beta Amyloid in samples from Human. It has been validated for IHC (fro).

Quick Overview for beta Amyloid antibody (N-Term) (ABIN1105349)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Immunohistochemistry (Frozen Sections) (IHC (fro))

Clone: NT 6C8

Product Details anti-beta Amyloid Antibody

Binding Specificity: N-Term

Sequence: DAEFRHDS

Specificity: This antibody recognizes the N-terminal sequence of beta amyloid peptides.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G affinity purified

Immunogen: The N-terminal sequence of human beta amyloid peptides

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Double distillated water is recommended and to adjust the final concentration to 1.00 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20 °C.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: Amyloid beta

Background: Beta amyloid, often abbreviated as A-beta, is a protein that builds up in the brains of persons with Alzheimer's disease, collecting in clumps called plaques or senile plaques. While some researchers question whether beta amyloid is the cause of the dementia, most agree that it is involved in the disruption of thinking that is a hallmark of the disease. In some cases of familial Alzheimer's disease, mutations in genes for the proteins called the presenilins lead to increased production of amyloid. Researchers have been looking at how presenilin-1 in particular contributes to the excess buildup of beta amyloid. Presenilin-1 apparently acts to increase the activity of gamma-secretase, an enzyme that changes a normal protein (amyloid precursor protein or APP) into beta amyloid itself. Furthermore, presenilin-1 might be gamma-secretase.Synonyms: ABPP, APPI, Alzheimer disease amyloid protein, Amyloid Precursor Protein, CVAP, Cerebral vascular amyloid peptide, PreA4, Protease nexin-II

Gene ID: 351

Pathways: Inflammasome