Poliovirus Receptor antibody (PE)

Catalog No. ABIN1105910

The Rat Monoclonal anti-Poliovirus Receptor antibody is suitable to detect Poliovirus Receptor in samples from Human. It has been validated for FACS.

Quick Overview for Poliovirus Receptor antibody (PE) (ABIN1105910)

Target: Poliovirus Receptor (PVR)

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This Poliovirus Receptor antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: TX21

Product Details anti-Poliovirus Receptor Antibody (PE)

Specificity: This antibody reacts with CD155.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G agarose

Immunogen: Recombinant human CD155 antigen

Isotype: IgG2a

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: PBS, 0.09 % NaN3, 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Alternative Name: CD155 / PVR

Background: CD155, transmembrane glycoprotein, is a member of the immunoglobulin superfamily also known as the human receptor for poliovirus (PVR). CD155 localizes in cell-matrix adhesions and cell-cell junctions. PV receptor CD155 complex with PV (PV1, PV2, and PV3). Both glycosylated and fully deglycosylated CD155 exhibited similar binding sites and orientations in the viral canyon for all three PV serotypes, showing that all three serotypes use a common mechanism for cell entry. It is reported that CD155 and CD112 (nectin-2/PRR-2) are ligands of CD226 (DNAM-1).Synonyms: Necl-5, Necl5, Nectin-like protein 5, PVS, Poliovirus receptor

Gene ID: 5817

NCBI Accession: NP_001129240

UniProt: P15151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interactome