cDNA Sequence AF251705 (AF251705) antibody
AF251705
Reactivity: Human
FACS
Host: Mouse
Monoclonal
TX45
unconjugated
1 image
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- Target See all cDNA Sequence AF251705 (AF251705) products
- cDNA Sequence AF251705 (AF251705)
- Reactivity
- Human
- Host
- Mouse
- Clonality
- Monoclonal
- Application
- Flow Cytometry (FACS)
- Specificity
- This antibody reacts with CD300d antigen.
- Cross-Reactivity (Details)
- Species reactivity (tested):Human (U937, Monocytes)
- Purification
- Protein A agarose
- Immunogen
- Ba/F3 transfectant expressing the human MAIR-II
- Clone
- TX45
- Isotype
- IgG1
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Concentration
- 1.0 mg/mL
- Buffer
- PBS containing 50 % glycerol, pH 7.2. No preservative is contained.
- Preservative
- Without preservative
- Handling Advice
- Avoid repeated freezing and thawing.
- Storage
- 4 °C/-20 °C
- Storage Comment
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- Target
- cDNA Sequence AF251705 (AF251705)
- Alternative Name
- MAIR-2 (Myeloid-Associated Immunoglobulin-Like Receptor) (AF251705 Products)
- Synonyms
- CLM4 antibody, Cd300c antibody, Cd300d antibody, DIgR1 antibody, Igsf7 antibody, Lmir2 antibody, MAIR-II antibody, CD300C molecule 2 antibody, Cd300c2 antibody
- Background
- Immune responses are regulated by opposing positive and negative signals triggered by the interaction of activating and inhibitory cell surface receptors with their ligands. Shibuya et al. identified novel paired activated and inhibitory immunoglobulin-like receptors, designated myeloid-associated immunoglobulin-like receptor (MAIR) I and MAIR-II, whose extracellular domains are highly conserved by each other. MAIR-I, expressed on the majority of myeloid cells, including macrophages, granulocytes, mast cells, and dendritic cells, contains the tyrosine-based sorting motif and the immunoreceptor tyrosine-based inhibitory motif-like sequences in the cytoplasmic domains. On the other hand, MAIR-II, expressed on subsets of peritoneal macrophages and B cells, associates with the immunoreceptor tyrosine-based activation motif-bearing adaptor DAP12. MAIR-I is also known as CD300a/ CMRF-35-like Ig-like molecule-8 (CLM-8)/leukocyte mono-Ig-like receptor 1 (LMIR1). MAIR-II is also known as CD300d/LMIR2/CLM-4/dendritic cell-derived Ig-like receptor 1 (DIgR1).
- Gene ID
- 140497
- NCBI Accession
- NP_598919
- UniProt
- Q7TSN2
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