Shigatoxin 1 antibody
Reactivity: E. coli
WB, Func, EIA
Host: Mouse
Monoclonal
13C4
unconjugated
-
- Target
- Shigatoxin 1
- Reactivity
- E. coli
-
Host
- Mouse
-
Clonality
- Monoclonal
-
Conjugate
- Un-conjugated
- Application
- Western Blotting (WB), Functional Studies (Func), Enzyme Immunoassay (EIA)
- Specificity
- The monoclonal antibody 13C4 recognizes the 1B subunit of Shiga-like toxin 1.
- Purification
- Protein G purified
- Clone
- 13C4
- Isotype
- IgG1
-
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Concentration
- 0.1 mg/mL
- Buffer
- PBS, 0.1 % BSA
- Storage
- 4 °C
- Storage Comment
- Product should be stored at 2-8 °C.
-
- Target
- Shigatoxin 1
- Target Type
- Chemical
- Background
- Shiga-like toxins (SLTs), are also called Verotoxins. Enterohemorrhagic Escherichia coli (EHEC) strains which are primarily of serotypes 0157:H7, 026:H11 and O111:H8 have been incriminated as etiologic agents of hemorrhagic colitis and Hemolytic-uremic syndrome, a generalized disease characterized by acute renal failure, thrombocytopenia, and microangiopathic hemolytic anemia. There are several distinct E.coli SLTs. SLT-I and SLT-II are produced by EHEC. SLT-I and Shiga toxin share >99?% deduced amino acid sequence homology, whereas SLT-I and SLT-II share about 60?% deduced amino acid sequence homology. SLT-I and SLT-II are antigenically distinct.The protein structure of the toxin consists of two domains: the A polypeptide that inhibits protein synthesis by targeting ribosomes, and the B polypeptide pentamer that binds to the eukaryotic cell receptor globotriaosylceramide (Gb3) leading to receptor-mediated endocytosis.Synonyms: SLT-1 B subunit, SLT-1b, SLT-Ib, Verocytotoxin 1 subunit B, Verotoxin 1 subunit B, sltB, stxB
- Gene ID
- 916677
- NCBI Accession
- NP_288672
- UniProt
- Q7DH26
-
You are here:
