NOD1 antibody (AA 2-31)

Catalog No. ABIN1169390

There is 1 publication for this product available. The Rabbit Polyclonal anti-NOD1 antibody is suitable to detect NOD1 in samples from Human. It has been validated for WB.

Quick Overview for NOD1 antibody (AA 2-31) (ABIN1169390)

Target: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-NOD1 Antibody

Binding Specificity: AA 2-31

Purpose: anti-Nod1 (human), pAb (AL184)

Specificity: Recognizes human Nod1.

Characteristics: Polyclonal Antibody. Recognizes human Nod1. Source: Rabbit. Applications: WB. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. Nod (CARD4) is a cytosolic pattern recognition molecule (PRRs) of the NLR (NOD-like receptor) family. Nod1 is widely expressed by many cell types and is implicated in sensing meso-diaminopimelic acid (meso-DAP)-containing PGN fragments, which are present in most Gramnegative bacteria and certain Gram-positive ones, like the Bacillus species. Upon activation, Nod1 initiates a pro-inflammatory response through NF-kappa signaling and is a key receptors in epithelial cells where it controls infections via the gastrointestinal system. Mutations in Nod1 have been reported to confer susceptibility to several inflammatory disorders including inflammatory bowel disease, atopic eczema and asthma.

Immunogen: Synthetic peptide corresponding to aa 2-31 (E2EQGHSEMEIIPSESHPHIQLLKSNRELLV31) of human Nod1.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

References for anti-NOD1 antibody (ABIN1169390)

Costello, Joyce, Abrahams: "NOD protein expression and function in first trimester trophoblast cells." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 57, Issue 1, pp. 67-80, (2006) (PubMed).

Target Details for NOD1

Target: NOD1 (Nucleotide-Binding Oligomerization Domain Containing 1 (NOD1))

Alternative Name: Nod1

Background:

Alternate Names/Synonyms: CARD4, Caspase Recruitment Domain-containing Protein 4, Nucleotide-binding Oligomerization Domain-containing Protein 1

Product Description: Nod (CARD4) is a cytosolic pattern recognition molecule (PRRs) of the NLR (NOD-like receptor) family. Nod1 is widely expressed by many cell types and is implicated in sensing meso-diaminopimelic acid (meso-DAP)-containing PGN fragments, which are present in most Gramnegative bacteria and certain Gram-positive ones, like the Bacillus species. Upon activation, Nod1 initiates a pro-inflammatory response through NF-kappa signaling and is a key receptors in epithelial cells where it controls infections via the gastrointestinal system. Mutations in Nod1 have been reported to confer susceptibility to several inflammatory disorders including inflammatory bowel disease, atopic eczema and asthma.

UniProt: Q8BHB0

Pathways: Activation of Innate immune Response, Positive Regulation of Endopeptidase Activity, Toll-Like Receptors Cascades, Inflammasome