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Granulin antibody
GRN
Reactivity: Human
WB, IHC, ELISA
Host: Guinea Pig
Polyclonal
unconjugated
Product Details anti-Granulin Antibody
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Target
See all Granulin (GRN) Antibodies
Granulin (GRN)
Reactivity
All reactivities for Granulin antibodies
Human
Host
All hosts for Granulin antibodies
Guinea Pig
Clonality
All clonalities for Granulin antibodies
Polyclonal
Conjugate
All conjugates for Granulin antibodies
This Granulin antibody is un-conjugated
Application
All applications for Granulin antibodies
Western Blotting (WB), Immunohistochemistry (IHC), ELISA
Specificity
Recognizes human progranulin. Detects a band of ~90 kDa by Western blot.
Cross-Reactivity
Human
Cross-Reactivity (Details)
Weakly cross-reacts with mouse progranulin. Cross-reacts with hGRN-C and hGRN-F.
Sterility
0.2 μm filtered
Immunogen
Recombinant human progranulin.
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
Lot specific
Buffer
0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
Preservative
Without preservative
Storage
4 °C,-20 °C
Storage Comment
Short Term Storage: +4°C Long Term Storage: -20°C Stable for at least 6 months after receipt when stored at -20°C.
Expiry Date
6 months
Target Details for Granulin
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Target
Granulin (GRN)
Alternative Name
Progranulin (GRN Products )
Synonyms
GRN antibody, grn antibody, wu:fb11g12 antibody, wu:fj18f05 antibody, MGC53354 antibody, DKFZp459H066 antibody, CLN11 antibody, GEP antibody, GP88 antibody, PCDGF antibody, PEPI antibody, PGRN antibody, epithelin antibody, acrogranin antibody, granulin precursor antibody, granulin a antibody, Granulins antibody, granulin L homeolog antibody, granulin antibody, GRN antibody, grna antibody, grn antibody, grn.L antibody, granulin antibody, ORF1 granulin antibody, Grn antibody
Target Type
Viral Protein
Background
Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.
UniProt
P28799
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