Granulin antibody

Catalog No. ABIN1169392

This Rat Polyclonal antibody specifically detects Granulin in WB and ELISA. It exhibits reactivity toward Mouse.

Quick Overview for Granulin antibody (ABIN1169392)

Target: Granulin (GRN)

Reactivity: Mouse

Host: Rat

Clonality: Polyclonal

Conjugate: This Granulin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-Granulin Antibody

Purpose: anti-Progranulin (mouse), pAb

Specificity: Recognizes mouse progranulin. Detects a band of ~90 kDa by Western blot. Weakly cross-reacts with human progranulin.

Cross-Reactivity (Details): Weakly cross-reacts with human progranulin.

Characteristics: Polyclonal Antibody. Recognizes mouse progranulin. Detects a band of ~90 kDa by Western blot. Weakly cross-reacts with human progranulin. Source: Rat. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

Sterility: 0.2 μm filtered

Immunogen: Recombinant mouse progranulin.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for Granulin

Target: Granulin (GRN)

Alternative Name: Progranulin

Background:

Alternate Names/Synonyms: Proepithelin, PEPI, PC Cell-derived Growth Factor

Product Description: Progranulin (PGRN) is a widely expressed pluripotent growth factor which plays a role in processes such as development, wound repair and inflammation by activating signaling cascades that control cell cycle progression and cell motility. Its function in the central nervous system is of interest, as mutations in the PGRN gene were found in cases of frontotemporal degeneration (FTLD). In addition, PGRN has also been linked to tumorigenesis. Progranulin is a biomarker for FTLD, other types of Alzheimer's Disease (AD) and potentially for MCI (Mild Cognitive Impairment). Additionally, PGRN is described as a new ligand of TNF receptors and a potential therapeutic against inflammatory disease like arthritis.

UniProt: P28798