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NOXA antibody
PMAIP1
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-NOXA Antibody
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Target
See all NOXA (PMAIP1) Antibodies
NOXA (PMAIP1)
(Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
Reactivity
Human, Mouse, Rat
Host
All hosts for NOXA antibodies
Rabbit
Clonality
All clonalities for NOXA antibodies
Polyclonal
Conjugate
All conjugates for NOXA antibodies
This NOXA antibody is un-conjugated
Application
All applications for NOXA antibodies
Western Blotting (WB)
Specificity
The antibody recognizes mainly ~16 kDa band. A ~34 kDa band is also detected to the lesser extent.
Purification
Protein A chromatography
Immunogen
Synthetic peptide surrounding amino acid 100 of human Noxa
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Alternatives
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Application Details
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Application Notes
Western Blot: 0.5-4 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
0.2 mg/mL
Buffer
BPS containing 0.5 % BSA, 30 % glycerol, and 0.01 % thimerosal
Preservative
Thimerosal (Merthiolate)
Precaution of Use
This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C
Storage Comment
Store the antibody undiluted (in aliquots) at -20 °C to -70 °C.
Target Details for NOXA
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Target
NOXA (PMAIP1)
(Phorbol-12-Myristate-13-Acetate-Induced Protein 1 (PMAIP1))
Alternative Name
NOXA (PMAIP1 Products )
Synonyms
TN3 antibody, PMAIP1 antibody, zgc:162379 antibody, APR antibody, NOXA antibody, Noxa antibody, phorbol-12-myristate-13-acetate-induced protein 1 antibody, PMAIP1 antibody, pmaip1 antibody, Pmaip1 antibody
Background
Noxa is a BH3-only member of the Bcl-2 family. Expression of Noxa gene involves direct activation of its promotor by p53. Increased expression of Noxa protein occurs in normal thymocytes but not in p53-deficient thymocytes. Coimmunoprecipitation data suggest that Noxa protein may interact with proteins belonging to the Bcl-2 family, such as Bcl-xL and Mcl-1. Blocking the endogenous Noxa induction results in the suppression of apoptosis. These suggest Noxa may represent a candidate mediator of p53-induced apoptosis.Synonyms: PMA-induced protein 1, PMAIP1, Phorbol-12-myristate-13-acetate-induced protein 1
Gene ID
5366
NCBI Accession
NP_066950
UniProt
Q13794
Pathways
p53 Signaling , Positive Regulation of Endopeptidase Activity , Regulation of Carbohydrate Metabolic Process , Positive Regulation of Response to DNA Damage Stimulus
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