FKBP8 antibody

Catalog No. ABIN127298

The Rabbit Polyclonal anti-FKBP8 antibody is suitable to detect FKBP8 in samples from Human, Mouse and Rat. It has been validated for WB.

Quick Overview for FKBP8 antibody (ABIN127298)

Target: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FKBP8 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FKBP8 Antibody

Specificity: The antibody recognizes a ~40 kDa band of FKBP38.

Purification: Protein A chromatography

Immunogen: Synthetic peptide surrounding amino acid 344 of mouse FKBP38

Application Details

Application Notes: Western Blot: 0.5 - 4 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: BPS containing 0.1 % BSA, 20 % glycerol, and 0.02 % thimerosal

Preservative: Thimerosal (Merthiolate)

Precaution of Use: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for FKBP8

Target: FKBP8 (FK506 Binding Protein 8, 38kDa (FKBP8))

Alternative Name: FKBP8 / FKBP38

Background: FK506-binding protein 38 (FKBP38), a member of the immunophilin family, has been implicated to play an important role in apoptosis through its involvement in the mechanism that targets Bcl-2 and Bcl-xL to the outer mitochondrial membrane (OMM). Suppression of endogenous FKBP38 by RNAi or transfection of a mutant FKBK38 missing the transmembrane domain necessary for mitochondrial insertion, resulted in the translocation of Bcl-2 and Bcl- xL from the OMM to the cytosol. It has also been suggested that FKBP38 may play a role in the cross-talk between the Bcl-2 and the Calcineurin/NF-AT apoptosis signaling pathways and in cell size regulation through interactions with tuberous sclerosis genes.Synonyms: 38 kDa FK506-binding protein, FK506-binding protein 8, Peptidyl-prolyl cis-trans isomerase FKBP8, Rotamase

Gene ID: 23770

NCBI Accession: NP_036313

UniProt: Q14318

Pathways: Autophagy