PDGFRB antibody

Catalog No. ABIN1302413

There is 1 publication for this product available. The Mouse Monoclonal anti-PDGFRB antibody is suitable to detect PDGFRB in samples from Human. It has been validated for ICC and FACS.

Quick Overview for PDGFRB antibody (ABIN1302413)

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PDGFRB antibody is un-conjugated

Application: Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 18A2

Product Details anti-PDGFRB Antibody

Purpose: Anti-Hu CD140b Purified

Cross-Reactivity (Details): Human

Characteristics: The monoclonal antibody 18A2 recognizes an extracellular epitope of CD140b / PDGF-RB, the 180-190 kDa beta chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative roles.

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: CD140b-transfected NIH 3T3 cells

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-4 μg/mL.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References for anti-PDGFRB antibody (ABIN1302413)

Fekete, Rojewski, Fürst, Kreja, Ignatius, Dausend, Schrezenmeier: "GMP-compliant isolation and large-scale expansion of bone marrow-derived MSC." in: PLoS ONE, Vol. 7, Issue 8, pp. e43255, (2012) (PubMed).

Target Details for PDGFRB

Target: PDGFRB (Platelet Derived Growth Factor Receptor beta (PDGFRB))

Alternative Name: CD140b

Background: Platelet derived growth factor receptor beta,CD140b / PDGF-RB (platelet-derived growth factor receptor beta) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140b forms homodimers, or heterodimerizes with CD140a / PDGF-RA. Whereas CD140a can have both pro-proliferative or anti-proliferative effects, the CD140b induces in various cell types their proliferation and migration. CD140b has also developmental roles in the cardiovascular system and is preferentially expressed on some tumours such as medulloblastoma.,PDGFRB, PDGFR1

Gene ID: 5159

UniProt: Q59F04

Pathways: Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Inositol Metabolic Process, Glycosaminoglycan Metabolic Process, Smooth Muscle Cell Migration, Platelet-derived growth Factor Receptor Signaling