ITGAL antibody

Catalog No. ABIN133274

Product Details anti-ITGAL Antibody

Target: ITGAL (Integrin alpha-L (ITGAL))

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This ITGAL antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Rat CD11a (LFA-1 chain )

Purification: Purified from ascitic fluid via Protein G Chromatography

Immunogen: Rat Splenic PHA blasts . Fusion Partner: Mouse myeloma cell line PAI . Donor: BALB/c spleen

Clone: WT-1

Isotype: IgG2a

Application Details

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/ml.

Buffer: Purified Ig buffered in PBS and 0.02% NaN . (Purified from ascitic fluid via Protein G Chromatography).

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Target Details for ITGAL

Target: ITGAL (Integrin alpha-L (ITGAL))

Alternative Name: CD11a (LFA-1 Chain) (ITGAL Products)

Synonyms: CD11A antibody, LFA-1 antibody, LFA1A antibody, (p180) antibody, Cd11a antibody, LFA-1A antibody, Ly-15 antibody, Ly-21 antibody, CD11a antibody, ITGAL antibody, integrin subunit alpha L antibody, integrin alpha L antibody, ITGAL antibody, Itgal antibody

Background: LFA-1 (lymphocyte function associated molecule-1) is one of the leukocyte integrins. It is a heterodimer consisting of and subunits of 160-170 kDa and 95-100 kDa respectively. LFA-1 promotes non-antigen dependent adhesion of T-cells to a variety of lymphoid cells that bear its complementary receptor I-CAM-1 (1). It has a broad distribution and is found on most common lymphocytes. ABIN133274is specific for the subunit of LFA-1. It inhibits homeotypic aggregation of PHA blasts and blocks the binding of rat lymphocytes to purified rat ICAM-1 (1). Applications include immunoprecipitation, flow cytometric analysis, immunohistochemistry (frozen), and functional testing.

Pathways: Activated T Cell Proliferation, Integrin Complex