CD40 antibody

Catalog No. ABIN133941

Product Details anti-CD40 Antibody

Target: CD40

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD40 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Specificity: Mouse CD40

Purification: Purified

Isotype: IgG2a

Application Details

Application Notes: This antibody is suitable for use in flow cytometry.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/ml

Storage: 4 °C

Target Details for CD40

Target: CD40

Alternative Name: CD40 (CD40 Products)

Synonyms: Bp50 antibody, CDW40 antibody, TNFRSF5 antibody, p50 antibody, AI326936 antibody, GP39 antibody, HIGM1 antibody, IGM antibody, IMD3 antibody, T-BAM antibody, TRAP antibody, Tnfrsf5 antibody, TNFSF5 antibody, CD40 molecule antibody, CD40 antigen antibody, CD40 antibody, Cd40 antibody

Background: Anti-mouse monoclonal antibody reacts with CD40 which is expressed on B lymphocytes and on a subset of both CD4 and CD8 T cells in the adult (but not neonatal) spleen . The level of CD40 on B cells is enhanced following activation by LPS . The interactions of CD40 with its ligand CD40L are responsible for generating humoral responses, germinal centre formation, and generating B cell memory . Stimulating cells with immobilized 3/23 mAb increases expression of CD86(B7.2) on B cells 1,3 . Though the 3/23 mAb itself is a weak mitogen, it produces a synergistic proliferative B cell response with IL-4 or with mitogenic antibodies against surface Ig 1,3 . Costimulation with 3/23 mAb and IL-4 rescues B cells from apoptosis induced by hypercross-linking of sIgM or sIgD . Other applications of the 3/23 mAb include IHC of acetone-fixed frozen sections This antibody is suitable for use in flow cytometry.

Pathways: NF-kappaB Signaling, Cellular Response to Molecule of Bacterial Origin, M Phase, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints