Integrin alpha 4 (ITGA4) antibody (Biotin) Primary Antibody
ITGA4
Reactivity: Mouse
FACS
Host: Rat
Monoclonal
PS-2
Biotin
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Catalog No. ABIN135077
$338.40
Plus shipping costs $45.00
0.5 mg
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- Target
- Integrin alpha 4 (ITGA4)
- Reactivity
- Mouse
- Host
- Rat
- Clonality
- Monoclonal
- Conjugate
- Biotin
- Application
- Flow Cytometry (FACS)
- Specificity
- Mouse/Human CD49d, Mr 150 kDa
- Characteristics
- Rat Anti-Mouse CD49d-BIOT
- Immunogen
- P815 cells
- Clone
- PS-2
- Isotype
- IgG2b
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-
- Application Notes
- Applications: FC - Quality tested , IHC-FS - Reported in literature , IP - Reported in literature , Adhesion - Reported in literature , Block - Reported in literature
- Working Dilutions: Flow Cytometry FITC and BIOT conjugates 2 g/106 cells PE conjugates 0.2 g/106 cells For flow cytometry, the suggested use of these reagents is in a final volume of 100 L
- Sample Volume
- 1 mL
- Restrictions
- For Research Use only
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- Concentration
- 0.5 mg/mL
- Buffer
- 0.5 mg in 1.0 mL of PBS/Sodium azide
- Preservative
- Sodium azide
- Precaution of Use
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handling Advice
- Protect conjugated products from light.
Each reagent is stable for the period shown on the bottle label if stored as directed. - Storage
- 4 °C
- Storage Comment
- Store at 2-8°C
-
- Target
- Integrin alpha 4 (ITGA4)
- Alternative Name
- CD49d (ITGA4 Antibody Abstract)
- Synonyms
- CD49D, IA4, LOC100219853, integrin subunit alpha 4, integrin alpha 4, integrin subunit alpha 4 S homeolog, ITGA4, Itga4, itga4.S
- Background
- CD49d, the 4 chain (100 kDa) of the VLA-4 integrin heterodimer (Mr 150 kDa) VLA-4 belongs to the 1-integrin family, which functions both as cell-matrix and cell-cell receptors.1-3 As a matrix receptor VLA-4 binds to an alternatively spliced domain of fibronectin, while as a cellular receptor it associates with its counter-receptor ligand VCAM-1. In addition to CD44/pgp-1, VLA-4 has been shown to be important for lymphopoiesis, and is also believed to be important for extravasation of lymphocytes into sites of inflammation as a second signal in addition to LFA/ICAM-1. CD49d/VLA-4 is expressed in low amounts on resting lymphocytes and monocytes, is absent or minimally detectable on stromal cells, whereas virtually all lymphoid and myeloid cells in bone marrow and in long-term culture are positive.
- Pathways
- Integrin Complex
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