Collagen Type I antibody

Catalog No. ABIN1385105

The Rabbit Polyclonal anti-Collagen Type I antibody has been validated for WB, IHC (p) and IF (p). It is suitable to detect Collagen Type I in samples from Human, Rat, Mouse, Cow, Dog and Pig.

Quick Overview for Collagen Type I antibody (ABIN1385105)

Target: Collagen Type I (COL1) (Collagen, Type I (COL1))

Reactivity: Human, Rat, Mouse, Cow, Dog, Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Collagen Type I antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-Collagen Type I Antibody

Cross-Reactivity: Cow, Dog, Human, Mouse, Pig, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Collagen alpha-1(I) chain

Isotype: IgG

Application Details

Application Notes: WB (1:100-500),IHC-P (1:100-500),IF (p) (1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Collagen Type I

Target: Collagen Type I (COL1) (Collagen, Type I (COL1))

Alternative Name: Collagen I

Background:

Synonyms: Collagen type I, Alpha 1 type I collagen, Alpha 2 type I collagen, COL1A1, COL1A2, Collagen I alpha 1 polypeptide, Collagen I alpha 2 polypeptide, Collagen Of Skin Tendon And Bone, Collagen Type 1, Collagen type I alpha 1, Collagen type I alpha 2, OI4, Osteogenesis Imperfecta Type IV, Pro alpha 1I collagen, Type I procollagen, CO1A1_HUMAN.

Background: Collagens are highly conserved throughout evolution and are characterised by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.

Molecular Weight: 161kDa

Gene ID: 1277