Herpes Simplex Virus Type 1 (HSV1) antibody

Catalog No. ABIN1385127

Product Details

Target: Herpes Simplex Virus Type 1 (HSV1)

Reactivity: Herpes Simplex Virus (HSV)

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: ELISA, Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Cross-Reactivity: Virus

Cross-Reactivity (Details): Herpes simplex virus 1

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from Herpes simplex virus 1 Neurovirulence factor ICP34.5

Isotype: IgG

Application Details

Application Notes: WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details

Target: Herpes Simplex Virus Type 1 (HSV1)

Alternative Name: HSV 1

Target Type: Virus

Background:

Synonyms: Herpes simplex virus 1, Herpes Simplex Virus, Herpes Simplex Virus Type 1, HSV 1, Human herpesvirus 1, Human herpesvirus type 1,ICP34_HHV1F, Infected cell protein 34.5, Neurovirulence factor ICP34.5, protein gamma(1)34.5, RL1

Background: Contributes to HSV resistance to the antiviral effects of alpha/beta interferon. Recruits the serine/threonine-protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor eIF-2A, thereby counteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR. Also down-modulates the host MHC class II proteins cell surface expression. Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, probably through its ability to maintain an environment favorable for viral replication.

UniProt: P08353