CACNA2D1 antibody (AA 571-610)

Catalog No. ABIN1386090

Product Details anti-CACNA2D1 Antibody

Target: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Binding Specificity: AA 571-610

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CACNA2D1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Pig,Horse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CACNA2/CACNA2D1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-CACNA2D1 antibody (ABIN1386090)

Chintalapudi, Maria, Di Wang, Bailey, Hysi, Wiggs, Williams, Jablonski: "Systems genetics identifies a role for Cacna2d1 regulation in elevated intraocular pressure and glaucoma susceptibility." in: Nature communications, Vol. 8, Issue 1, pp. 1755, (2018) (PubMed).

Target Details for CACNA2D1

Target: CACNA2D1 (Calcium Channel, Voltage-Dependent, alpha 2/delta Subunit 1 (CACNA2D1))

Alternative Name: CACNA2/CACNA2D1 (CACNA2D1 Products)

Synonyms: CACNA2D1 antibody, DKFZp469K2211 antibody, CACNA2 antibody, CACNL2A antibody, CCHL2A antibody, Ca(v)alpha2delta1 antibody, Cacna2 antibody, Cchl2a antibody, CCHLA2 antibody, DHSCCA antibody, calcium voltage-gated channel auxiliary subunit alpha2delta 1 antibody, calcium channel, voltage-dependent, alpha 2/delta subunit 1 antibody, calcium channel, voltage-dependent, alpha2/delta subunit 1 antibody, CACNA2D1 antibody, cacna2d1 antibody, Cacna2d1 antibody

Background:

Synonyms: Calcium channel L type DHPR alpha 2 subunit, CA2D1_HUMAN, CACN A2, CACNA2, CACNA2D1, CACNL2A, Calcium channel L type alpha 2 polypeptide, Calcium channel voltage dependent alpha 2/delta subunit 1, CCHL2A, Dihydropyridine receptor alpha 2 subunit, Dihydropyridine sensitive L type calcium channel alpha 2/delta subunit, Dihydropyridine sensitive L type calcium channel subunits alpha 2/delta, H_DJ0560O14.1, L type calcium channel subunit alpha 2, MHS 3, MHS3, Voltage dependent calcium channel subunit alpha 2/delta 1, Voltage gated calcium channel subunit alpha 2/delta 1, Voltage-dependent calcium channel subunit delta-1, Voltage-gated calcium channel subunit alpha-2/delta-1, WUGSC:H_DJ0560O14.1.

Background: Voltage-dependent calcium channels are essential for the release of neurotransmitters. Cacna2d1 (calcium channel, voltage-dependent, alpha 2/delta subunit 1), also known as CACNA2, CCHL2A, MHS3 or CACNL2A, is a 1,091 amino acid single-pass type I membrane protein that contains one VWFA domain and one cache domain. Expressed in skeletal muscle, aorta tissues and in the central nervous system (CNS), Cacna2d1 functions as an alpha-2/delta subunit of voltage-dependent calcium channels and plays an important role in calcium current density, as well as in excitation-contraction coupling. The Cacna2d1 precursor is proteolytically processed to produce two functional subunits, designated alpha-2-1 and delta-1, which are disulfide-linked to one another.