CBFA2T2 antibody (AA 321-420)

Catalog No. ABIN1386136

This Rabbit Polyclonal antibody specifically detects CBFA2T2 in WB, ELISA, IF (cc), IF (p), IHC (p) and IHC (fro). It exhibits reactivity toward Human.

Quick Overview for CBFA2T2 antibody (AA 321-420) (ABIN1386136)

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CBFA2T2 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CBFA2T2 Antibody

Binding Specificity: AA 321-420

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MTGR1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CBFA2T2

Target: CBFA2T2 (Core-binding Factor, Runt Domain, alpha Subunit 2, Translocated To, 2 (CBFA2T2))

Alternative Name: Mtgr1

Background:

Synonyms: AML1 MTG8, CBFA2T2, Core binding factor runt domain alpha subunit 2 translocated to 2, EHT, ETO homolog on chromosome 20, ETO homologous on chromosome 20, MTG 8 like protein, MTG 8 related protein 1, MTG8 like protein, MTG8 related protein 1, MTG8-like protein, MTG8-related protein 1, MTG8R_HUMAN, MTGR 1, Myeloid translocation gene related protein 1, Myeloid translocation related protein 1, Myeloid translocation-related protein 1, p85, Protein CBFA2T2, ZMYND 3, ZMYND3.

Background: May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8,21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region.Tissue specificity:Ubiquitously expressed in fetal and adult tissues. Highly expressed in adult brain, heart, lung, kidney, lymph node, appendix, thymus, testis, uterus, small intestine, prostate and thymus.

Gene ID: 9139