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Nicalin antibody (AA 401-500)

NCLN Reactivity: Human WB, ELISA, IHC (p), ICC, IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN1386554
  • Target See all Nicalin (NCLN) Antibodies
    Nicalin (NCLN)
    Binding Specificity
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-500
    Reactivity
    • 28
    • 15
    • 12
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 25
    • 2
    • 2
    Rabbit
    Clonality
    • 28
    • 1
    Polyclonal
    Conjugate
    • 13
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    This Nicalin antibody is un-conjugated
    Application
    • 12
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Predicted Reactivity
    Human,Mouse,Rat
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human Nicalin
    Isotype
    IgG
    Top Product
    Discover our top product NCLN Primary Antibody
  • Application Notes
    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    4 °C,-20 °C
    Storage Comment
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Expiry Date
    12 months
  • Target
    Nicalin (NCLN)
    Alternative Name
    Nicalin/NCLN (NCLN Products)
    Synonyms
    NET59 antibody, RGD1309355 antibody, wu:fb07e09 antibody, wu:fk52a06 antibody, zgc:77236 antibody, 3100002P13Rik antibody, AW120537 antibody, nicalin antibody, NCLN antibody, Bm1_29425 antibody, LOC100280679 antibody, Ncln antibody, ncln antibody
    Background

    Synonyms: NCLN, NCLN_HUMAN, NET59, Nicalin, Nicalin homolog zebrafish, Nicastrin like protein, Nicastrin-like protein.

    Background: Nicastrin is an integral part of the Alzheimers associated gamma-secretase complex. Nicalin, a nicastrin-like protein, is not associated with gamma-secretase but rather interacts with NOMO (Nodal modulator). Nodals are TGF beta signaling factors that control various cell fate decisions during embryonic body planning stages in vertebrate development. The Nicalin/NOMO complex acts to regulate the nodal signaling factors during gastrulation. This regulation most often affects the development of the axial mesoderm. Nodal signaling is an important factor for melanoma cell invasiveness and tumorigenicity and inhibition of this signal can promote melanoma cells reverting back toward a melanocyte phenotype.

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