BEND7 antibody

Catalog No. ABIN1387161

Product Details anti-BEND7 Antibody

Target: BEND7 (BEN Domain Containing 7 (BEND7))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This BEND7 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human C10orf30/BEND7

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for BEND7

Target: BEND7 (BEN Domain Containing 7 (BEND7))

Alternative Name: BEND7 (BEND7 Products)

Synonyms: C10orf30 antibody, 1110017O21Rik antibody, E130319B15Rik antibody, RGD1305898 antibody, BEN domain containing 7 antibody, si:ch211-220f12.4 antibody, BEND7 antibody, si:ch211-220f12.4 antibody, Bend7 antibody

Background:

Synonyms: BEN domain-containing protein 7, BEND7, Chromosome 10 open reading frame 30, FLJ40283, MGC35247, BEND7_HUMAN.

Background: BEND7 is a 519 amino acid protein that contains a BEN domain. BEN domain mediates proteinDNA and proteinprotein interactions during chromatin organization and transcription. BEN domain may play a role in organization of viral DNA during replication or transcription. BEND7 exists as three independently spiced isoforms and the gene that encodes BEND7 maps to chromosome 10p13. Chromosome 10 contains over 800 genes and 135 million nucleotides, making up nearly 4.5 % of the human genome. PTEN is an important tumor suppressor gene located on chromosome 10 and, when defective, causes a genetic predisposition to cancer development known as Cowden syndrome. The chromosome 10 encoded gene ERCC6 is important for DNA repair and is linked to Cockayne syndrome which is characterized by extreme photosensitivity and premature aging. Tetrahydrobiopterin deficiency and a number of syndromes involving defective skull and facial bone fusion are also linked to chromosome 10.