CALHM1 antibody (AA 161-260)

Catalog No. ABIN1387430

The Rabbit Polyclonal anti-CALHM1 antibody is suitable to detect CALHM1 in samples from Human. It has been validated for WB, IF (cc), IF (p), IHC (p) and IHC (fro).

Quick Overview for CALHM1 antibody (AA 161-260) (ABIN1387430)

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CALHM1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-CALHM1 Antibody

Binding Specificity: AA 161-260

Purpose: CALHM1 Polyclonal Antibody

Predicted Reactivity: Human,Mouse,Rat,Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CALHM1/FAM26C

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CALHM1

Target: CALHM1 (Calcium Homeostasis Modulator 1 (CALHM1))

Alternative Name: CALHM1/FAM26C

Background:

Synonyms: CAHM1_HUMAN, Calcium homeostasis modulator 1, Calcium homeostasis modulator protein 1, CALHM1, FAM26C, Family with sequence similarity 26, member C, MGC39514, MGC39617, Protein FAM26C.

Background: CALHM1 is a 346 amino acid multi-pass endoplasmic reticulum membrane protein that belongs to the FAM26 family. CALHM1 co-localizes with GRP 78 to the endoplasmic reticulum. Predominantly expressed in adult brain, CALHM1 may be a pore-forming ion channel that controls cytosolic Ca2+ permeability and cytosolic Ca2+ concentration in the cell. It is suggested that CALHM1 regulates amyloid precursor protein proteolysis and aggregated amyloid-beta peptides levels in a Ca2+ dependent manner. CALHM1 homomultimerizes and shares strong sequence similarities with the selectivity filter of the NMDA receptor, which generates a large Ca2+ conductance across the plasma membrane. CALHM1 may be a potential factor involved in the pathogenesis of Alzheimer's disease.